Progress in the Chemistry of Organic Natural Products 115 (eBook)

A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch (Herausgeber)

eBook Download: PDF

2021 | 1st ed. 2021
VII, 203 Seiten
Springer International Publishing (Verlag)
978-3-030-64853-4 (ISBN)

Infos

This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca²⁺ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.

Produkt-Details

• Erscheint lt. Verlag: 2.4.2021
• Reihe/Serie: Progress in the Chemistry of Organic Natural Products
• Reihe/Serie: Progress in the Chemistry of Organic Natural Products
• Zusatzinfo: VII, 203 p. 144 illus., 42 illus. in color.
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Schlagworte: Anticancer Drug Development • Bioactive Compounds • cryptolepine • decanolides • Lead compound in drug development • natural product synthesis and isolation • thapsigargin • total synthesis
• ISBN-10: 3-030-64853-2 / 3030648532
• ISBN-13: 978-3-030-64853-4 / 9783030648534