Progress in the Chemistry of Organic Natural Products 115

A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch (Herausgeber)

Buch | Hardcover

VII, 203 Seiten

2021 | 1st ed. 2021
Springer International Publishing (Verlag)
978-3-030-64852-7 (ISBN)

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This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca²⁺ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.

Total Synthesis of Decanolides (Nonanolides) with a Special Focus on Olefin Metathesis.- From Plant to Patient: Thapsigargin.- Antileishmanial Activity of Lignans and Neolignans.- Cryptolepine as a Lead to new Antiprotozoal Agents.- Biologically Active Constituents from Plants of the Genus Xanthium.

Erscheinungsdatum	08.04.2021
Reihe/Serie	Progress in the Chemistry of Organic Natural Products
Zusatzinfo	VII, 203 p. 144 illus., 42 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	489 g
Themenwelt	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Botanik
	Naturwissenschaften ► Chemie ► Organische Chemie
Schlagworte	Anticancer Drug Development • Bioactive Compounds • cryptolepine • decanolides • Lead compound in drug development • natural product synthesis and isolation • thapsigargin • total synthesis
ISBN-10	3-030-64852-4 / 3030648524
ISBN-13	978-3-030-64852-7 / 9783030648527
Zustand	Neuware