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Simulation for Designing Clinical Trials -

Simulation for Designing Clinical Trials

A Pharmacokinetic-Pharmacodynamic Modeling Perspective

Hui Kimko, Stephen B. Duffull (Herausgeber)

Buch | Hardcover
424 Seiten
2002
Crc Press Inc (Verlag)
978-0-8247-0862-7 (ISBN)
CHF 299,95 inkl. MwSt
Supplying a framework for employing simulation as an experiment, this book discusses how to clinically trial designs according to their probability for success. It gives techniques to define distributions of virtual subjects' characteristics, and methods to determine the sensitivity of the trial design.
Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to clinical trial designs according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.

Hui C. Kimko, Stephen B. Duffull

Introduction to Simulation for Design of Clinical Trials. Models for Simulation. Computation in Simulation. Analyses of the Simulations. Perspectives on Clinical Trial Simulation. Applications. Index.

Erscheint lt. Verlag 12.12.2002
Verlagsort Bosa Roca
Sprache englisch
Maße 156 x 234 mm
Gewicht 940 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Naturwissenschaften Biologie
Technik
ISBN-10 0-8247-0862-8 / 0824708628
ISBN-13 978-0-8247-0862-7 / 9780824708627
Zustand Neuware
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