Simulation for Designing Clinical Trials

A Pharmacokinetic-Pharmacodynamic Modeling Perspective

Hui Kimko, Stephen B. Duffull (Herausgeber)

Buch | Hardcover

424 Seiten

2002
Crc Press Inc (Verlag)
978-0-8247-0862-7 (ISBN)

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Supplying a framework for employing simulation as an experiment, this book discusses how to clinically trial designs according to their probability for success. It gives techniques to define distributions of virtual subjects' characteristics, and methods to determine the sensitivity of the trial design.

Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to clinical trial designs according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.

Hui C. Kimko, Stephen B. Duffull

Introduction to Simulation for Design of Clinical Trials. Models for Simulation. Computation in Simulation. Analyses of the Simulations. Perspectives on Clinical Trial Simulation. Applications. Index.

Erscheint lt. Verlag	12.12.2002
Verlagsort	Bosa Roca
Sprache	englisch
Maße	156 x 234 mm
Gewicht	940 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Naturwissenschaften ► Biologie
	Technik
ISBN-10	0-8247-0862-8 / 0824708628
ISBN-13	978-0-8247-0862-7 / 9780824708627
Zustand	Neuware