Zinc Signaling (eBook)

Toshiyuki Fukada, Taiho Kambe (Herausgeber)

eBook Download: PDF

2019 | 2nd ed. 2019
VIII, 413 Seiten
Springer Singapore (Verlag)
978-981-15-0557-7 (ISBN)

Infos

This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.

Professor. Toshiyuki Fukada, Ph.D., Faculty of Pharmaceutical Sciences, Molecular and Cellular Physiology, Tokushima Bunri University, Japan.

Associate professor. Taiho Kambe, Ph.D., Department of Applied Molecular Biology, Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Japan. 

 

Inhalt

Foreword 5
Contents 7
Chapter 1: Opening the Second Era of Zinc Signaling Study 9
1.1 Introduction 9
1.2 Progresses, Questions, and Directions 10
References 12
Chapter 2: Regulation of Cellular Zinc Ions and Their Signaling Functions 13
2.1 Proteins Regulating Zinc: Buffering and Muffling in Cellular Zinc Homeostasis 15
2.2 Metallothioneins 16
2.3 Zinc Transporters 18
2.3.1 ZnTs (Solute Carrier Family SLC30A1-10) 20
2.3.2 ZIPs (Zrt/Irt-Like Proteins) (Solute Carrier Family SLC39A1-14) 21
2.4 MTF-1 21
2.5 Signaling with Inorganic Ions: Ca2+ and Zn2+ 21
2.6 Zinc Regulating Proteins (Zinc/Zn2+ Signaling) 23
2.6.1 Intracellular Regulation 23
2.6.2 Extracellular Regulation 25
2.7 Zinc Functions in Health and Disease 25
References 26
Chapter 3: Zinc Transporter Proteins: A Review and a New View from Biochemistry 31
3.1 Introduction 31
3.2 History of ZNT and ZIP Family Proteins 32
3.3 ZNT Transporters 41
3.3.1 Biochemical and Structural Properties of Bacterial ZNT Homologs 41
3.3.2 Properties of ZNT Transporter Proteins 41
3.3.3 Biochemical Characterization of the ZNT Subgroups 45
3.3.3.1 ZNT1 and ZNT10 Subgroup 45
3.3.3.2 ZNT2, ZNT3, ZNT4, and ZNT8 Subgroup 45
3.3.3.3 ZNT5 and ZNT7 Subgroup 46
3.3.3.4 ZNT6 Subgroup 47
3.4 ZIP Transporters 47
3.4.1 Biochemical and Structural Properties of Bacterial ZIP Homologs 47
3.4.2 Properties of ZIP Family Proteins 49
3.4.3 Biochemical Characterization of the ZIP Subfamilies 50
3.4.3.1 ZIP-I Subfamily 50
3.4.3.2 ZIP–II Subfamily 51
3.4.3.3 gufA Subfamily 51
3.4.4 Biochemical Characterization of LIV-1 Subfamily 51
3.4.4.1 ZIP4 and ZIP12 Subgroup 52
3.4.4.2 ZIP8 and ZIP14 Subgroup 52
3.4.4.3 ZIP5, ZIP6, and ZIP10 Subgroup 52
3.4.4.4 ZIP7 and ZIP13 Subgroup 53
3.5 Concluding Remarks and Perspectives 54
References 54
Chapter 4: The Metallothionein-Zinc Landscape: How It Shapes Antimicrobial Immunity 65
4.1 Introduction 66
4.2 Low Zinc Spells a High Infection Risk 67
4.3 The Zinc Pill: To Take or Not to Take? 68
4.4 Zinc: A Prominent Driver on the Road to Innate Defense 68
4.5 The MT-Zinc Immune-Landscape: An Old Axis with a New Tale 71
4.6 The MT-Zinc Axis in Infection 73
4.6.1 Bacterial Infection 73
4.6.2 Fungal Infection 74
4.6.3 Viral and Parasitic Infections 75
4.7 Survival Edge: Microbes (Aim to) Get the Upper Hand 76
4.8 Concluding Remarks 77
References 78
Chapter 5: Role of Zinc Signaling in Mast Cell, Basophil, T Cell, and B Cell 86
5.1 Introduction 86
5.2 Zinc Homeostasis 87
5.3 Role of Zinc as a Second Messenger 89
5.4 Zinc Signaling Mediated by Antigen Receptors 90
5.4.1 Fc?RI-Mediated Zinc Signaling 90
5.4.2 BCR-Mediated Zinc Signaling 92
5.4.3 TCR-Mediated Zinc Signaling 93
5.5 Role of Zinc and Zinc Signaling in Cytokine Production 94
5.5.1 Role of Zinc in Mast Cell-Mediated Cytokine Production 95
5.5.2 Role of Zinc in Basophil-Mediated Cytokine Production 96
5.6 Zinc Wave Is a Key Regulator of Cytokine Production in Immune Cells 98
5.7 Perspective 99
References 100
Chapter 6: Review: The Role of Zinc Signaling in Reproduction 105
6.1 Zinc Signaling in Female Reproduction 106
6.1.1 Gamete Genesis 106
6.1.2 Oocyte Activation and Fertilization 107
6.1.3 The Role of Zinc Signaling in Fertilization: The Discovery of the “Zinc Sparks” 110
6.1.4 The Expression and Function of Zinc Transporters in Mammalian Oocytes 112
6.1.5 Pregnancy: Embryo Implantation, Decidualization, and Placentation 114
6.1.6 Zinc and Pregnancy 116
6.2 Zinc Signaling in Male Reproduction 120
References 121
Chapter 7: Zinc Signaling in Skeletal Muscle 128
7.1 Introduction 128
7.2 Muscle Contraction 129
7.3 Muscle Growth 132
7.4 Skeletal Muscle Repair from Injury, Atrophy, and Cachexia 133
7.5 Skeletal Muscle-Based Glucose Metabolism 135
7.6 Future Perspectives 138
References 138
Chapter 8: Zinc Signaling in Aging Heart Function 143
8.1 Introduction 144
8.2 Role of Zinc in Mammalian Heart Function 145
8.3 Aging and Insufficient Heart Function 147
8.4 Role of the Mitochondria in Aging Heart 148
8.5 Role of Zinc in Mitochondrial Dysfunction in Aging Heart 151
8.6 Role of Zinc Transporters in Mammalian Heart Function 154
8.7 Role of Zinc Transporter ZIP14 in Aging Mammalian Heart Function 156
8.8 Conclusion 158
References 160
Chapter 9: Zinc Signaling in the Life and Death of Neurons 169
9.1 Zinc Rocks! 170
9.2 Zinc Is a Neurotransmitter 170
9.3 Intracellular Zinc Signaling 174
9.3.1 Translocation of Synaptic Zinc 174
9.3.2 Intracellular Liberation of Zinc 175
9.3.3 A Zinc/Potassium Continuum in Neuronal Cell Death 177
9.4 Tapping the Zinc/Potassium Continuum as a Neuroprotective Strategy 180
9.5 Concluding Remarks 181
References 182
Chapter 10: Possible Therapeutic Roles of Metallothionein-3 and Zinc in Endosome-Autophagosome-Lysosome Pathway (EALP) Dysfunction in Astrocytes 190
10.1 Introduction 191
10.2 Contributors to Lysosomal Dysfunction in Aging-Related Neurodegenerative Diseases and Their Mechanisms 192
10.3 Possible Measures to Restore Lysosomal Function 193
10.4 Emerging Role of Metallothionein-3 (MT3) in Regulation of Endocytosis and Lysosome Functions in Astrocytes 195
10.5 Measures Increasing Cytosolic and/or Lysosomal Free Zinc Levels May Help Overcome Lysosomal Dysfunction 197
10.6 Conclusions 199
References 200
Chapter 11: Zinc in Neurodegeneration 204
11.1 Introduction 204
11.2 How Does Zinc Contribute to Neurodegeneration? 206
11.2.1 Zinc and Autophagy 206
11.2.2 Zinc and Protein Aggregation 208
11.2.3 Zinc and Oxidative Stress 210
11.2.4 Zinc and Synaptic Function/ Learning and Memory 211
11.2.5 Zinc, Excitotoxicity and Mitochondria 212
11.2.6 Zinc and Inflammation 214
11.2.7 Zinc and Alzheimer’s Disease 215
11.2.8 Zinc and Parkinson’s Disease 216
11.2.9 Zinc and Amyotrophic Lateral Sclerosis 217
11.2.10 Zinc and Ageing 218
11.2.11 Zinc and Traumatic Brain Injury 219
11.3 Conclusion 220
References 221
Chapter 12: Role of Zinc Transporters in Type 2 Diabetes and Obesity 232
12.1 Zinc and Pancreatic ? Cells 232
12.2 Zinc Deficiency and Diabetes 235
12.3 Physiological Functions of Zinc Transporters 235
12.4 Structure and Function of ZnT8 236
12.5 The Role of ZnT8 in Glucose Homeostasis 238
12.6 Reconsideration of SLC30A8 Activity and the Risk of Diabetes 240
12.7 Zinc Transporter ZIP13 Inhibits Adipocyte Browning 240
12.8 Therapeutic Application of Zinc Transporters Toward Obesity and Diabetes 242
References 243
Chapter 13: Zinc Signals in Immunology 246
13.1 Zinc Signals in Immunology 247
13.2 Zinc Homeostasis and the Immune System 247
13.3 Types of Zinc Signals 252
13.4 Zinc Signal and the Innate Immunity 254
13.5 Zinc Signal and the Adaptive Immunity 260
References 270
Chapter 14: Zinc Signals in Inflammation 281
14.1 Introduction 281
14.2 Zinc Signals and Inflammation 283
14.2.1 Zinc Signals 283
14.2.2 Zinc Homeostasis and Signaling Pathways 283
14.2.2.1 Zinc and the MAPK Pathway 283
14.2.2.2 Zinc and the NF?B Pathway 285
14.2.2.3 Zinc and GPCRs 286
14.2.2.4 Zinc and Other Signaling Pathways 287
14.2.2.5 Zinc and ROS 287
14.2.3 Zinc Signals in Acute Inflammation 288
14.2.3.1 Zinc and the Common Cold 288
14.2.3.2 Zinc and Sepsis 289
14.2.4 Zinc Signals in Chronic Inflammation 289
14.2.4.1 Zinc and Allergic Airway Inflammation 289
14.2.4.2 Zinc and Gastrointestinal (GI) Disorders 290
14.2.4.3 Zinc and Inflamm-Aging 291
14.3 Altered Zinc Homeostasis and Immune Cell Signaling in Inflammation 293
14.3.1 Zinc Signals and the Innate Immune System 293
14.3.1.1 Monocyte/Macrophages 293
14.3.1.2 Dendritic Cells 295
14.3.1.3 Neutrophils 295
14.3.1.4 Mast Cells 296
14.3.2 Zinc Signals and the Adaptive Immune System 296
14.3.2.1 T-Lymphocytes 296
14.3.2.2 B-Lymphocytes 297
14.4 Zinc Toxicity 298
14.5 Conclusions 299
References 300
Chapter 15: Zinc Transporters and Zinc Signaling in Skin Formation and Diseases 307
15.1 Zinc Transporters and Zinc Signaling 307
15.2 ZIP1 309
15.3 ZIP2 310
15.4 ZIP4 310
15.5 ZIP7 312
15.6 ZIP10 313
15.7 ZIP13 315
15.8 Other ZIP Family Members 316
15.9 Conclusion 316
References 316
Chapter 16: Post-translational Mechanisms of Zinc Signalling in Cancer 320
16.1 Introduction 320
16.2 Control of Intracellular Zinc Level 322
16.3 Classification and Predicted Membrane Topology of Zinc Transport Proteins 322
16.3.1 ZIP Channels 323
16.3.2 ZnT Transporters 325
16.4 Zinc and Cancer 326
16.5 ZIP Channels in Breast Cancer 327
16.5.1 ZIP7 in Breast Cancer 328
16.5.2 ZIP6 in Breast Cancer 330
16.5.3 ZIP10 in Breast Cancer 332
16.6 Zinc Signalling in Prostate Cancer 332
16.7 Post-translational Modifications of ZIP Channels 333
16.7.1 Phosphorylation 333
16.7.2 Proteolytic Cleavage of ZIP Channels 334
16.8 Conclusions 337
References 338
Chapter 17: Zinc Signaling (Zinc’ing) in Intestinal Function 347
17.1 Introduction 347
17.2 The Role of Zinc in Intestinal Function 350
17.3 Zinc Transporters in the Digestive Tract 352
17.3.1 Transporters Responsible for Uptake 352
17.3.2 Transporters Responsible for Intracellular Zn2+ Homeostasis 354
17.4 Intestinal Function of ZnR/GPR39 355
17.5 Conclusions and Future Directions 357
References 357
Chapter 18: In Situ Imaging of Zinc with Synthetic Fluorescent Probes 364
18.1 Introduction 364
18.2 Fluorogenic Probes 365
18.2.1 Design Principles and Applications 365
18.2.2 Visualizing Zinc in Cells and Tissues 370
18.2.3 Limitations and Artifacts 373
18.3 Ratiometric Fluorescent Probes 374
18.4 Fluorescent Probes for Two-Photon Excitation Microscopy 376
18.4.1 Design Principles and Applications 376
18.4.2 Ratiometric Probes for Two-Photon Microscopy 380
18.5 Conclusions 383
References 384
Chapter 19: Zinc Signals in Biology 388
19.1 Introduction 388
19.2 Zinc Homeostasis and Signaling in Bacteria 389
19.3 Zinc Homeostasis in Bacteria 389
19.4 Zinc-Responsive Two-Component Signal Transduction Systems in Bacteria 391
19.5 Zinc Homeostasis and Signaling in Fungi 395
19.6 Zinc Signals and Homeostasis in Caenorhabditis elegans 398
19.7 Zinc Homeostasis and Signaling in Fish 401
19.8 Conclusions 402
References 403
Index 410

Produkt-Details

• Erscheint lt. Verlag: 13.12.2019
• Zusatzinfo: VIII, 413 p. 70 illus., 56 illus. in color.
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Schlagworte: Bone • Cancer • Diabetes • immunology • Metallothionein • Neuron • Skin • zinc biology • Zinc signals • Zinc transporters
• ISBN-10: 981-15-0557-8 / 9811505578
• ISBN-13: 978-981-15-0557-7 / 9789811505577