The Pangenome
Springer International Publishing (Verlag)
978-3-030-38280-3 (ISBN)
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications.
The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes.
The book's respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory.
Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
Hervé Tettelin Dr. Tettelin is a Professor of Microbiology and Immunology at the University of Maryland School of Medicine, Institute for Genome Sciences. Over the course of his career, Dr. Tettelin developed an extensive expertise in microbial genomics, functional genomics, comparative genomics, and bioinformatics. He led seminal genome sequencing and analysis projects for many important human bacterial pathogens and related commensals, including the initial genomes of Streptococcus agalactiae (group B Streptococcus, GBS). In collaboration with the group of Dr. Rino Rappuoli (GlaxoSmithKline, former Chiron Vaccines and Novartis Vaccines and Diagnostics), Dr. Tettelin pioneered the fields of reverse vaccinology and pan-genome analyses. The former makes use of genomics to identify novel protein candidates for vaccine development, which was first applied to Neisseria meningitidis; this approach resulted in the recent commercialization of the Bexsero® (4CMenB) vaccine. The latter is the focus of this book. Dr. Tettelin has conducted many studies of bacterial diversity and transcriptional profiling using DNA microarrays and RNA-seq, as well as functional genomics analyses to identify genes essential for virulence using Tn-seq. He has also supervised the development of bioinformatics tools to compare closely related bacterial genomes in the context of infectious diseases. Duccio Medini
Part 1: Genomic diversity and the pan-genome concept.- Chapter 1: The pan-genome: a data-drivendiscovery in biology.- Chapter 2: The prokaryotic species concept and challenges.- Chapter 3: Bacterial guide on how to design a diversified gene portfolio.- Chapter 4: A review of pan-genome tools and recent studies.- Part 2: Evolutionary biology of pan-genomes.- Chapter 5: Structure and dynamics of bacterial populations: pan-genome ecology.- Chapter 6: Bacterial microevolution and the pan-genome.- Chapter 7: Pan-genomes and selection: the public goods hypothesis.- Chapter 8: A pan-genomic perspective on the emergence, maintenance and predictability of antibiotic resistance.- Part 3: Pan-genomics: an open, evolving discipline.- Chapter 9: Metapangenome: at the crossroad of pangenomics and metagenomics.- Chapter 10: Pan-genome flux balance analysis towards pan-phenomes.- Chapter 11: Bacterial epigenomics: epigenetics in the age of population genomics.- Chapter 12: Eukaryotic pan-genomes.- Chapter 13: Computational strategies for eukaryotic pan-genome analyses.
| Erscheinungsdatum | 05.05.2020 |
|---|---|
| Zusatzinfo | XIV, 307 p. 47 illus., 43 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 653 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie |
| Schlagworte | Acquired Resistance • Adaptive Evolution • Bacterial Ecology, Microevolution • Bacterial Species Concept • Bioinformatic Genomics • comparative genomics • Computational tools • Core Dispensable Genome • gene transfer • Genomic Diversity • Metagenomics • Microbial Population Analysis • open access • Pan-epigenome • Pangenome Profile • Pan-metagenomics • Pan-microbiomics • Pan-phenomes • Selection, Recombination, Composition • Supra-Genome Analysis |
| ISBN-10 | 3-030-38280-X / 303038280X |
| ISBN-13 | 978-3-030-38280-3 / 9783030382803 |
| Zustand | Neuware |
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