Cheating Cell (eBook)

How Evolution Helps Us Understand and Treat Cancer

Athena Aktipis (Autor)

eBook Download: PDF | EPUB

2020
256 Seiten
Princeton University Press (Verlag)
978-0-691-18608-5 (ISBN)

Infos

A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don't necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer's evolutionary origins, researchers can come up with more effective, revolutionary treatments.Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer's ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn't mean we should give up on treating cancer-in fact, evolutionary approaches offer new and promising options for the disease's prevention and treatments that aim at long-term management rather than simple eradication. Looking across species-from sponges and cacti to dogs and elephants-we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future-and that we cannot win a war against evolution-treatments can become smarter, more strategic, and more humane.Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer's fundamental nature and our relationship to it.

Produkt-Details

• Erscheint lt. Verlag: 24.3.2020
• Zusatzinfo: 19 b/w illus.
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie ► Evolution
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Schlagworte: adaptive immune system • Adaptive Oncogenesis • adaptive therapy • Apoptosis • Azra Raza • Bacteria • Battle • Beat • Behavior • Benign • biologist • Biology • biopsy • brca1 • BRCA mutation • Breast • Breast Cancer • Cactus • cactus cancer • cancer cell • cancer prevention • Cancer the Evolutionary Legacy • cancer transmission • Cell Biology • cell death • cell division • cell growth • Cell Migration • cell signaling • cellular • cellular differentiation • cheater • Chemotherapy • childhood cancer • Childhood Leukemia • chromosome • Chronic myelogenous leukemia • circulatory system • clinical trial • colonies • colony • conflict • containment • cooperation theory • Disease • DNA damage (naturally occurring) • DNA repair • Doctor • Drugs • Ecology • ecosystem • Emperor of All Maladies • epigenetics • Esophageal cancer • evasion • Evolution • evolutionary biology • evolutionary dynamics • Evolutionary pressure • extracellular matrix • Fertile • fertility • Fight • Fitness • foraging • free rider • Gene • gene expression • Gene product • genes • Genetic heterogeneity • Genomic • Geriatric • germline • Growth factor • human behavior • human sharing • Immune • immunity • immunology • immunotherapy • Infection • inflammation • Innate immune system • James DeGregori • Kat Arney • kin selection • leukemia • Lung • Lung Cancer • Malignant • Management of cancer • maternal • Medical • Medicine • melanoma • Mel Greaves • Metabolism • Metastasis • metastasize • microbial mediators • microenvironment • Microorganism • Mobile Genetic Elements • Motility • Multicellularity • Multicellular organism • Mutation • Natural selection • Nodule (medicine) • Nucleic acid sequence • nutrient • Oncogene • oncologist • Oncology • organism • ovarian cancer • Ovary • p53 • parasitism • Parental investment • Paternal • pathogen • Pathology • Peto's paradox • petri dish • Physician • predation • primary tumor • Prostate • Prostate Cancer • Protein • Public Health • radiologist • Radiology • Regulator • Reproduction • Reproductive success • resistance • Richard Dawkins • Risk • Selfish Monsters • Sexually Transmitted Infection • sexual reproduction • siddhartha mukherjee • Somatic • Stem Cell • susceptibility • Tasmanian devil • Tazmanian devil • The Evolution of Cooperation • The First Cell • the selfish gene • The Tumor • Thoracic • Thyroid Cancer • Trade-off • transmissible cancer • Transmission • transposable element • tree of life • Trophoblast • tumor microenvironment • tumor suppressor gene • Unicellular organism • vulnerability • white blood cell • womb • Wound • wound healing • Writing
• ISBN-10: 0-691-18608-1 / 0691186081
• ISBN-13: 978-0-691-18608-5 / 9780691186085