Psychiatric Disorders

Methods and Protocols

Buch | Hardcover

728 Seiten

2019 | 2nd ed. 2019
Humana Press Inc. (Verlag)
978-1-4939-9553-0 (ISBN)

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This second edition volume expands on the previous edition with updates to chapters and new chapters discussing the latest research in neuropsychiatric diseases. The chapters in this book are organized into eleven sections and cover the diversity and utility of animal models of psychiatric disorders, their development, modelling, and pathophysiological and molecular profiles. Part One looks at experimental modeling of neuropsychiatric studies and the usefulness and need of animal models. Parts Two and Three focus on experimental models of neuropsychiatric illnesses, including self-injurious behavior, bipolar disorder, anxiety, and learning and decision-making testing. Parts Four and Five discuss animal models of substance abuse. Part Six describes protocols to examine animal models related to maladaptive eating habits and behaviors. Parts Seven and Eight cover neurodegenerative diseases stemming from natural causes (aging), abnormal genetic backgrounds, or those brought on by trauma. Part Nine talks about inflammatory and metabolic alteration profiles relevant to autism spectrum disorders and depression. Parts Ten and Eleven conclude the book with a discussion on genetics, epigenetics, and system biology in the field of psychiatric disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Psychiatric Disorders: Methods and Protocols, Second Edition is a useful resource for graduates, postdoctoral workers, and established scientists working in the fields of behavioral and molecular neuropsychiatric research.

Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development.- Qualitative vs. Quantitative Methods in Psychiatric Research: Updated.- Animal Models of Self-Injurious Behavior: An Update.- Bipolar Disorder: Its Etiology and How to Model in Rodents.- Recent Updates in Modeling Risky Decision Making in Rodents.- The Pemoline Model of Self-Injurious Behavior: An Update.- Rodent Models of Adaptive Value Learning and Decision Making.- The Visually-Mediated Social Preference Test: A Novel Technique to Measure Social Behavior and Behavioral Disturbances in Zebrafish.- Animal Models of Intoxication by Metal Elements: A Focus on Neurobehavioral Injuries.- Animal Models of Early-Life Adversity.- Nicotine Self-Administration as Paradigm for Medication Discovery for Smoking Cessation: Recent Findings in Medications Targeting the Cholinergic System.- The Human Laboratory and Drug Development in Alcohol Use Disorder: Recent Updates.- Rodent Models of Methamphetamine Misuse: Mechanisms of Methamphetamine Action and Comparison of Different Rodent Paradigms.- Recent Updates in Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs.- Methods for Evaluating the Interaction between Social Stress and Environmental Enrichment in Animal Models of Nicotine Addiction.- An Animal Model of Alcohol Binge Drinking: Chronic-Intermittent Ethanol Administration in Rodents.- Animal Models of Eating Disorders.- Protocols Using Rodents to Model Eating Disorders in Humans.- Updates in PTSD Animal Models Characterization.- Overview on Emotional Behavioral Testing in Rodent Models of Pediatric Epilepsy.- Neurological Exam in Rats following Stroke and Traumatic Brain Injury.- Y Shaped Maze to Test Spontaneous Object Recognition and Temporal Order Memory after Traumatic Brain Injury.- An Animal Model to Test Reversal of Cognitive Decline Associated with Beta Amyloid Pathologies.- Methods in Emotional Behavioral Testing in Immature Epilepsy Rodent Models.- Methods in Electrode Implantation and Wiring for Long-Term Continuous EEG Monitoring in Rodent Models of Epilepsy and Behavioral Disturbances.- Behavior Model for Assessing Decline in Executive Function during Aging and Neurodegenerative Diseases.- Animal Model for Leigh Syndrome.- Peripheral Biomarkers of Inflammation in Depression: Evidence from Animal Models and Clinical Studies.- The Contribution of Inflammation to Autism Spectrum Disorders: Recent Clinical Evidence.- Interleukin-2 and the Septohippocampal System: An Update on Intrinsic Actions and Autoimmune Processes Relevant to Neuropsychiatric Disorders.- The Probiotic Mixture VSL#3 Reverses Olanzapine-Induced Metabolic Dysfunction in Mice.- Genetic Studies of Tic Disorders and Tourette’s Syndrome.- MeCP2 Dysfunction in Rett Syndrome and Neuropsychiatric Disorders.- Behavioral Characterization of MeCP2 Dysfunction-Associated Rett Syndrome and Neuropsychiatric Disorders.- The Role of Epigenetics in Addiction: Clinical Overview and Recent Updates.- Chromatin Immunoprecipitation Techniques in Neuropsychiatric Research.- Chromatin Immunoprecipitation Assay for Analyzing Transcription Factor Activity at the Level of Peripheral Myelin Gene Promoters.- Study of Myelin Genes Expression in the Central Nervous System using Real Time PCR.- Enhanced Molecular Appreciation of Psychiatric Disorders through High-Dimensionality Data Acquisition and Analytics.

Erscheinungsdatum	25.07.2019
Reihe/Serie	Methods in Molecular Biology ; 2011
Zusatzinfo	64 Illustrations, color; 17 Illustrations, black and white; XXIII, 728 p. 81 illus., 64 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	Alzeimers Disease. • Anorexia • anxiety disorder • Biomarkers • HUPO
ISBN-10	1-4939-9553-7 / 1493995537
ISBN-13	978-1-4939-9553-0 / 9781493995530
Zustand	Neuware