Alpha-Synuclein
Humana Press Inc. (Verlag)
978-1-4939-9123-5 (ISBN)
Cutting-edge and thorough, Alpha-Synuclein: Methods and Protocols is a valuable reference guide that aids researchers working on topics related to alpha-synuclein and its various aspects.
Assays for Neuronal Defects Caused by Early Formation of α-Synuclein Inclusions in Primary Cultured Neurons.- Immunohistochemical Detection of Alpha-Synuclein in Unfixed Human Brain Tissue.- Kinetic Measurements of Endocytosis and Exocytosis in Cultured Neurons.- Detection of Misfolded α-Synuclein Aggregates in Cerebrospinal Fluid by the Protein Misfolding Cyclic Amplification Platform.- Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain using Pre-Formed Fibrils.- Quantification of Alpha-Synuclein in Biological Fluids by Electrochemiluminescence-Based Detection.- Alpha-Synuclein Proximity Ligation Assay (AS-PLA) in Brain Sections to Probe for Alpha-Synuclein Oligomers.- Studying α-Synuclein Conformation by Intact-Cell Crosslinking.- C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques.- Recombinant Expression and Purification of N-Acetylated Alpha-Synuclein.- CircularDichroism and Isothermal Titration Calorimetry to Study the Interaction of α-Synuclein with Membranes.- Yeast-Based Screens to Target Alpha-Synuclein Toxicity.- Probing Structural Changes in Alpha Synuclein by Nuclear Magnetic Resonance Spectroscopy.- Measuring Mitochondrial Dysfunction Caused by Soluble α-Synuclein Oligomers.- Monitoring α-Synuclein Proteotoxicity in Drosophila Models.- Detection of α-Synuclein in Biological Samples using Mass Spectrometry.- Single-Molecule FRET Detection of Early-Stage Conformations in α-Synuclein Aggregation.- In Situ Peroxidase Labelling and Mass-Spectrometry of Alpha-Synuclein in Rat Cortical Neurons.- Probing Alpha-Synuclein Conformations by Electron Paramagnetic Resonance (EPR) Spectroscopy.- Expression and Purification of Untagged α-Synuclein.- Generation and Analysis of Viral Vector Mediated Rodent Models for Parkinson’s Disease.
Erscheinungsdatum | 17.03.2019 |
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Reihe/Serie | Methods in Molecular Biology ; 1948 |
Zusatzinfo | 55 Illustrations, color; 11 Illustrations, black and white; XII, 289 p. 66 illus., 55 illus. in color. |
Verlagsort | Totowa, NJ |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
Naturwissenschaften ► Biologie ► Humanbiologie | |
Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
Naturwissenschaften ► Biologie ► Zoologie | |
Schlagworte | Amyloid Formation • endocytosis • Exocytosis • protein-protein interaction • Rodent models • Toxicity |
ISBN-10 | 1-4939-9123-X / 149399123X |
ISBN-13 | 978-1-4939-9123-5 / 9781493991235 |
Zustand | Neuware |
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