Inflammation-Associated Depression: Evidence, Mechanisms and Implications

Robert Dantzer, Lucile Capuron (Herausgeber)

Buch | Softcover

X, 356 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-84581-4 (ISBN)

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Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book "Inflammation-Associated Depression" is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.

Section 1: Evidence for inflammation-associated depression.- Evidence for inflammation-associated depression.- Role of inflammation in the development of neuropsychiatric symptom domains.- Inflammation-associated comorbidity.- Section 2: Mechanisms of inflammation-associated depression.- Mechanisms of inflammation-associated depression Immune-to-brain communication pathways and cytokines.- Immune-to-brain communication pathways.- Mechanisms of inflammation-associated depression.- Role of the kynurenine metabolism pathway.- Depression in autoimmune diseases.- Stress-induced microglia activation.- Inflammation effects on brain glutamate.- The role of dopamine.- Brain structures implicated in inflammation-associated depression.- Role of kynurenine metabolism pathway.- Suicidality. Section 3: Clinical implications of inflammation-associated depression.- The promise and limitations of anti-inflammatory agents.- Are non-steroidal anti-inflammatory drugs.- Does diet matter?- Role of neuroimunological factors.

"This book covers important and growing field of knowledge associated with the role of inflammation in depression. ... The book is well written and presented with many diagrams and illustrations. It covers the gap in this area of psychiatry research and potential for clinical practice and will be of interest for clinicians and researchers worldwide." (Branka Aukst Margetic, Alcoholism and Psychiatry Research, Vol. 54 (01), June, 2018)

"The authors describe the current research data surrounding the role of inflammation and its impact on depression. ... Each chapter begins with an abstract, identified keywords, and an outline of the chapter. Most chapters contain helpful graphics and conclude withreferences. ... To my knowledge, this is the first book focused solely on the role of inflammation in psychiatry, which was confirmed by a quick internet search." (Aaron Plattner, Doody's Book Reviews, April, 2017)

Erscheinungsdatum	05.03.2022
Reihe/Serie	Current Topics in Behavioral Neurosciences
Zusatzinfo	X, 356 p. 30 illus., 20 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	563 g
Themenwelt	Medizin / Pharmazie ► Studium
Themenwelt	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	Biological psychiatry • Cardiovascular disorders • Cytokine • Depression • Indoleamine 2,3 dioxygenase • inflammation • Kynurenine • Obesity • Phenylalanine • Psychopharmacology • Tetrahydrobiopterin
ISBN-10	3-319-84581-0 / 3319845810
ISBN-13	978-3-319-84581-4 / 9783319845814
Zustand	Neuware