Molecular Machines (eBook)

A Materials Science Approach

Giovanni Zocchi (Autor)

eBook Download: PDF

2018
192 Seiten
Princeton University Press (Verlag)
978-1-4008-9006-4 (ISBN)

Infos

Molecular Machines presents a dynamic new approach to the physics of enzymes and DNA from the perspective of materials science. Unified around the concept of molecular deformability—how proteins and DNA stretch, fold, and change shape—this book describes the complex molecules of life from the innovative perspective of materials properties and dynamics, in contrast to structural or purely chemical approaches. It covers a wealth of topics, including nonlinear deformability of enzymes and DNA; the chemo-dynamic cycle of enzymes; supra-molecular constructions with internal stress; nano-rheology and viscoelasticity; and chemical kinetics, Brownian motion, and barrier crossing. Essential reading for researchers in materials science, engineering, and nanotechnology, the book also describes the landmark experiments that have established the materials properties and energy landscape of large biological molecules.Molecular Machines is also ideal for the classroom. It gives graduate students a working knowledge of model building in statistical mechanics, making it an essential resource for tomorrow's experimentalists in this cutting-edge field. In addition, mathematical methods are introduced in the bio-molecular context—for example, DNA conformational transitions are used to illustrate the transfer matrix formalism. The result is a generalized approach to mathematical problem solving that enables students to apply their findings more broadly.Molecular Machines represents the next leap forward in nanoscience, as researchers strive to harness proteins, enzymes, and DNA as veritable machines in medicine, technology, and beyond.

Autor

Giovanni Zocchi is professor of physics at the University of California, Los Angeles. He is the coauthor of Physics in Molecular Biology.

Produkt-Details

• Erscheint lt. Verlag: 10.7.2018
• Zusatzinfo: 94 b/w illus.
• Verlagsort: Princeton
• Sprache: englisch
• Themenwelt: Naturwissenschaften
• Schlagworte: allosteric control • Allosteric enzyme • Amplitude • atoms • ATP hydrolysis • Base Pair • base pairing • base stacking • Brownian motion • Cells • chemical kinetics • chemical structure • Complementary sequences • Conformational change • Contour length • Cooperativity • Cutoff frequency • Debye model • Deformation (engineering) • deformations • Degrees of freedom (mechanics) • Diffusion • Diffusion Equation • Dissipation • Dissociation (chemistry) • Dissociation constant • DNA • DNA deformation • DNA melting • DNA molecules • Einstein relation (kinetic theory) • elastic energy • Elasticity (physics) • Electrostatics • energy landscape • Enthalpy • Entropic Force • Entropy • Enzyme • enzyme assay • enzyme deformability dynamics • Enzyme kinetics • enzyme operation • enzymes • Equilibrium • Equipartition theorem • ergodic hypothesis • folded protein • free energy • Gas in a box • Gaussian network model • gel electrophoresis • gene expression • Guanylate kinase • Hooke's law • Hydrogen bond • Hydrophobe • Hyperbolic function • ideal gas • Ion chromatography • Ising Model • Johnson–Nyquist noise • Kinematics • Kinesin • Lagrangian • Langevin Dynamics • Langevin Equation • Laplace transform • laws of thermodynamics • Le Chatelier's principle • length scale • Ligand (biochemistry) • linear elasticity • Main effect • Materials Science • Mathematical Methods • mean free path • Melting • molecular deformability • molecular machine • molecular machines • molecular motor • Molecule • nano-rheology • nanorod • nearest neighbor • nearest neighbor model • nonequilibrium state • non-equilibrium thermodynamics • Nonequilibrium Thermodynamics • nonlinear deformability • nonlinear system • Nucleic acid thermodynamics • Oligomer • Oligonucleotide • Optical Tweezers • Persistence length • Phase diagram • phase transition • Polymer • Protein • Protein Folding • Quasistatic process • Quenching (fluorescence) • Random coil • Rate equation • Redox • resonance • rheology • Rheometer • Rotational diffusion • self-diffusion • softening • statics • Statistical Mechanics • statistical weight • Steady state • Surface energy • Temperature • thermal fluctuation • Thermodynamic Equilibrium • Thermodynamic Limit • Thermodynamic system • Universality class • van der Waals force • viscoelasticity • worm-like chain • zipper model
• ISBN-10: 1-4008-9006-3 / 1400890063
• ISBN-13: 978-1-4008-9006-4 / 9781400890064