Multiscale Mechanobiology in Tissue Engineering

Damien Lacroix, Marzia Brunelli, Cécile Perrault, Adrien Baldit, Maryam Shariatzadeh (Autoren)

Buch | Hardcover

203 Seiten

2018 | 1st ed. 2019
Springer Verlag, Singapore
978-981-10-8074-6 (ISBN)

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This book focuses on the mechanobiological principles in tissue engineering with a particular emphasis on the multiscale aspects of the translation of mechanical forces from bioreactors down to the cellular level. The book contributes to a better understanding of the design and use of bioreactors for tissue engineering and the use of mechanical loading to optimize in vitro cell culture conditions. It covers experimental and computational approaches and the combination of both to show the benefits that computational modelling can bring to experimentalists when studying in vitro cell culture within a scaffold. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, this work provides a novel approach to the use of engineering tools for the optimization of biological processes and its application to regenerative medicine. The volume is a valuable resource for researchers and graduate students studying mechanobiology and tissue engineering. For undergraduate students it also provides deep insight into tissue engineering and its use in the design of bioreactors. The book is supplemented with extensive references for all chapters to help the reader to progress through the study of each topic.

Damien Lacroix, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKMarzia Brunelli, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKCecile Perrault, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKAdrien Baldit, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKMaryam Shariatzadeh, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKAna Campos Marin, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKAndre Castro, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKSara Barreto, INSIGNEO Institute for in silico Medicine, University of Sheffield, UK

A review of bioreactors and mechanical stimuli.- Multiscale simulation of bioreactor design and in vitro conditions.- Mechanical stimulation in a PCL additive manufacturing scaffold.- Towards a new approach to analyse quality control and morphometric variability in a scaffold.- Computational simulation of cell seeding in a tissue engineering scaffold.- Collagen gel cell encapsulation to study mechanotransduction.- Collagen gel cell encapsulation to study the effect of fluid flow on mechanotransduction.- Computational modeling of collagen hydrogel.- Mechanical load transfer at the cellular level.- Quantification of CSK mechanics and deformation in relation to cellular functioning.- The future of tissue engineering design for bioreactor stimulation.

Erscheinungsdatum	19.09.2018
Reihe/Serie	Frontiers of Biomechanics ; 3
Zusatzinfo	82 Illustrations, color; 20 Illustrations, black and white; XIII, 203 p. 102 illus., 82 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Mathematik / Informatik ► Mathematik ► Wahrscheinlichkeit / Kombinatorik
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
	Technik ► Maschinenbau
	Technik ► Medizintechnik
Schlagworte	bioreactor design • Cell Mechanics • Computational simulations • multiscale approach • Tissue engineering
ISBN-10	981-10-8074-7 / 9811080747
ISBN-13	978-981-10-8074-6 / 9789811080746
Zustand	Neuware