Sepsis
Morgan & Claypool Publishers (Verlag)
978-1-61504-756-7 (ISBN)
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical studies in this group of critically ill patients. Mainly for those reasons, there is no therapy approved so far to overcome the underlying immune dysregulation. This book provides an overview about the state of the art of sepsis diagnostics and potential future therapies. Chapter 1 focuses on the immunologic staging of sepsis—the key for successful treatment of the dysregulated hot response. Chapter 2 reveals similarities in the immune response in sepsis and cancer—opening new avenues for novel therapies. Chapter 3 introduces an important modulator of the immune response—the endogenous cannabinoid system and elucidates its role in organ dysfunction in sepsis. Facing the increasing bacterial resistance to classical antibiotics, Chapter 4 discusses two unique mechanisms to treat infection and inflammation in sepsis: iron chelation, and the sphingosine pathway. The authors, all experts in experimental and clinical sepsis research, seek to provide further understanding of the complexities of the immune response as the physiological basis for the development of new therapeutics in sepsis.
Dr. Christian Lehmann is Professor of Anesthesia, Pharmacology, Microbiology and Immunology, and Physiology and Biophysics at Dalhousie University, Halifax, NS, Canada. He is also Staff Anesthesiologist in the Department of Anesthesia, Nova Scotia Health Authority, Halifax. Dr. Lehmann has 25 years of experience in experimental and clinical inflammation research. He established experimental intravital imaging laboratories in Berlin and Greifswald, Germany. His focus of research is the microcirculation, i.e., capillary blood flow, cell-cell-interactions, and endothelial pathology. He participated in diverse German and international clinical multicenter trials, e.g., in sepsis. He joined Dalhousie University in 2007 and currently supervises research in three laboratories with modern equipment to study the microcirculation under various conditions experimentally and clinically. He is the author of more than 150 original publications, 13 book chapters and almost 200 published abstracts. He is a member of the Dalhousie Inflammation Group (DIG), the Microcirculation Diagnostics and Applied Studies (MiDAS) research group and the Cystic Fibrosis Translational Research (CFTR) group. In 2009, he founded the RESIST (Research in the Endocannabinoid System in Inflammation, Sepsis and Trauma) group with Dr. Melanie Kelly and others at Dalhousie University. Dr. Juan Zhou is Associate Professor of Anaesthesia, Pain Management, and Perioperative Medicine at Dalhousie University. She received her M.D. from Xian Medical University in 1986, and practiced as an ophthalmologist at the Shaanxi Provincial Hospital in China. After moving to Canada, Dr. Zhou obtained her M.Sc. in Biology in 1993 and her Ph.D. in Immunology in 2001 from Dalhousie University. Dr. Zhou's principal research interests are in immunomodulation in transplantation tolerance and inflammation. Her current research focus is investigating the role of the endocannabinoid system in inflammatory disorders including experimental sepsis, central nerve system injury-induced immunosuppression, and interstitial cystitis. Dr. Zhou has over 60 peer-reviewed scientific journal publications, books, and book chapters. She is an avid badminton player, and she enjoys canoeing through the lakes of Nova Scotia. Charles C. Caldwell, Ph.D., is Professor of Surgery at the University of Cincinnati. Professor Caldwell received his B.A. in Chemistry from the University of California, San Diego, and in 1998, completed a Ph.D. in Biochemistry at San Diego State University. He subsequently conducted his post-doctoral studies at the Laboratory of Immunology, NIAID at the NIH campus in Bethesda, Maryland. He joined the University of Cincinnati in 2003. Professor Caldwell's research interests are centered on characterizing and developing therapies to influence the host response to sepsis and trauma. He has published over 85 peer-reviewed manuscripts and reviews. Professor Caldwell's studies have been funded by the National Institutes of Health, Shriner's Hospitals of North America, Department of Defense, and Pfizer. He is the director of the basic and translational research division within the Department of Surgery, research member of the Shriner's Hospital for Children at Cincinnati, and graduate faculty in Immunobiology, Cincinnati Children's Hospital Medical Center. D. Neil Granger, Ph.D., is Boyd Professor and Head of the Department of Molecular and Cellular Physiology at the LSU Health Sciences Center in Shreveport, Louisiana. His current research is focused on the role of the microcirculation in acute and chronic inflammation, and how risk factors for cardiovascular disease influence microvascular function. Granger has served on the editorial boards of the Heart & Circulation, GI & Liver, and Cell sections of the American Journal of Physiology, as well as Circulation Research, Microcirculation, Shock, Pathophysiology, Free Radical Biology & Medicine, Lymphatic Research and Biology, and Nitric Oxide Biology & Chemistry. He was Editor-in-Chief of Microcirculation and an Associate Editor of the American Journal of Physiology: GI & Liver Physiology. Dr. Granger was a member of the Clinical Sciences-2, Cardiovascular & Renal, and General Medicine-A2 Study Sections and the Gastrointestinal Mucosal Pathobiology Study Sections. He also served on several peer review panels and policy committees for the American Heart Association, the Research Committee of the American Gastroenterological Association, the Board of Directors of the Federation of American Societies for Experimental Biology, and the Physiology Test Committee of the National Board of Medical Examiners. Granger served as President of the American Physiological Society (APS) and the Microcirculatory Society (MCS). He has received several awards and honors for his research, including the APS Bowditch Award, the Distinguished Research Award from the GI Section of the APS, the Landis Award from the US Microcirculatory Society, the Laerdal Award from the Society for Critical Care Medicine, the McKenna Memorial Award from the Canadian Association of Gastroenterology, the Dolph Adams Award from the Society for Leukocyte Biology, the Career of Distinction Award from the Oxygen Society, the Nishimaru-Tsuchiya International Award from the Japanese Microcirculatory Society, the Robert M Berne Lectureship from the APS, and the Benjamin W. Zweifach Award from the US Microcirculatory Society. He was also designated a Highly Cited Investigator by the Institute for Scientific Information. Joey P. Granger, Ph.D., is the Billy S. Guyton Distinguished Professor, Professor of Physiology and Medicine, Director of the Center for Excellence in Cardiovascular Renal Research, and Dean of the School of Graduate Studies in the Health Sciences at the University of Mississippi Medical Center in Jackson, MS. He earned his doctorate from the University of Mississippi School of Medicine in 1983. Dr. Granger currently served as President of the American Physiological Society and is an Associate Editor for Hypertension. He has also served as the Editor of the Council for High Blood Pressure Newsletter and an Associate Editor for News in Physiological Sciences and American Journal of Physiology. He has served as a member of Editorial Boards of American Journal of Hypertension, American Journal of Physiology-Renal, American Journal of Physiology: Regulatory and Integrative Physiology, Journal of CardioMetabolic Syndrome and the Journal of the American Society of Hypertension. He has served on scientific study sections for the American Heart Association (AHA), National Institutes of Health, NASA, and the Veterans Administration. He now serves as chair of the Hypertension and Microcirculation NIH study section. He has received several awards including the E.H. Starling Distinguished Lecture Award, the Bodil M. Schmidt-Nielsen Distinguished Mentor and Scientist Award, and the Bowditch Award from the American Physiological Society (APS), the Dahl Memorial Lecture of the AHA, American Society of Hypertension Young Scholar Award, the International Society of Hypertension Demuth Research Award, Inter-American Society of Hypertension Young Investigator Award, the Regulatory and Integrative Physiology (APS) Young Investigator Award and the Harold Lamport Award (APS) and an Established Investigator Award from the AHA. Granger's research has been continuously funded by the NIH since 1984. His research has focused on the role of the kidneys in the pathogenesis of hypertension, and the role of endothelial and neurohormonal factors in mediating hypertension in animal models of preeclampsia. His laboratory is also investigating the role of the renal endothelin system in salt-sensitive hypertension.
Introduction
Immunologic Staging of Sepsis: Finding the Right Lock for the Key
Sepsis and Cancer: Similarities in the Immune Response and Treatment with Novel Therapies
Organ Dysfunction and the Endocannabinoid System in Sepsis
Novel Antibiotic Approaches in Sepsis
Summary
References
Lead Author Biographies
Contributing Author Biographies
| Erscheinungsdatum | 28.09.2017 |
|---|---|
| Reihe/Serie | Colloquium Series on Integrated Systems Physiology: From Molecule to Function |
| Mitarbeit |
Herausgeber (Serie): D. Neil Granger, Joey P. Granger |
| Verlagsort | San Rafael |
| Sprache | englisch |
| Maße | 152 x 229 mm |
| Gewicht | 525 g |
| Themenwelt | Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung |
| Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
| ISBN-10 | 1-61504-756-5 / 1615047565 |
| ISBN-13 | 978-1-61504-756-7 / 9781615047567 |
| Zustand | Neuware |
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