RNA Nanotechnology and Therapeutics

Peixuan Guo, Farzin Haque (Herausgeber)

Buch | Softcover

611 Seiten

2017
CRC Press (Verlag)
978-1-138-07528-3 (ISBN)

Infos

Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.

Autor

Peixuan Guo is the Director of the NIH Nanomedicine Development Center at the University of Cincinnati, Ohio and the Director of the NIH/NCI Cancer Nanotechnology Platform Partnership Program: RNA Nanotechnology for Cancer Therapy at Purdue University, Indiana.

Inhalt

The Emerging Field of RNA Nanotechnology. Uniqueness, Advantages, Challenges, Solutions, and Perspectives in Therapeutics Applying RNA Nanotechnology. Kink Turn Structural Motif in RNA. RNA Nanotechnology: Learning from Biologically Active RNA Nanomachines. Natural Selection and Structural Polymorphism of RNA 3D Structures Involving GNRA Loops and Their Receptor Motifs . RNA Junction Motifs as Scaffolds for Construction of Multifunctional RNA Nanoparticles. Role of Dynamics in RNA Nanostructure Design. RNA Three-Dimensional Structure Determination Using Experimental Constraints. Nucleotide Chemistry for RNA Nanoparticle Labeling, Conjugation, and Synthesis. RNA Conjugations and Ligations for RNA Nanotechnology. Atom-Specific Mutagenesis of RNAs for Structure, Function, and Therapeutics Studies. Atomic Force Microscopy of RNA: Imaging and Beyond. Single-Molecule Approach to Study RNA Nanoparticles. Fabrication Methods for RNA Nanoparticle Assembly Based on Bacteriophage phi29 Packaging RNA Structural Features. Synthetic RNA–Protein Nanostructures and Their Potential Applications. DNA Nanotechnology as Reference for RNA Nanotechnology. Thermodynamically Stable RNA Three-Way Junction for Constructing Multifunctional Nanoparticles for Delivery of Therapeutics. Design and Construction of RNA Nanoparticles Targeting Prostate Cancer. Conjugation of RNA Aptamer to RNA Nanoparticles for Targeted Drug Delivery. Extracellular Membrane Vesicles and Extracellular Membrane Vesicle–Based Therapeutics for Brain Diseases. Pharmacokinetics and Pharmacodynamics of RNA Nanoparticles. RNA Nanotechnology in Sensing, Detection, and Disease Diagnosis. Potentials of RNA Aptamers for Viral Detection and Treatment. Application of RNA Aptamers in Nanotechnology and Therapeutics . Aptamers Targeting a Subunit or a Conformation of Glutamate Ion Channel Receptors. Application of MicroRNAs in RNA Nanotechnology and Antiviral Therapeutics. MicroRNAs: Biology and Role in RNA Nanotechnology. Current Advances in Self-Assembly RNAi Nanoparticles. Self-Assembly of siRNA Containing Nanoparticles. Index.

Produkt-Details

• Erscheinungsdatum: 07.11.2017
• Zusatzinfo: 15 Tables, black and white; 146 Illustrations, black and white
• Verlagsort: London
• Sprache: englisch
• Maße: 178 x 254 mm
• Gewicht: 453 g
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Technik ► Umwelttechnik / Biotechnologie
• ISBN-10: 1-138-07528-0 / 1138075280
• ISBN-13: 978-1-138-07528-3 / 9781138075283
• Zustand: Neuware