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Small Molecule Therapeutics for Schizophrenia

Sylvain Celanire, Sonia Poli (Herausgeber)

Buch | Softcover

VII, 323 Seiten

2016 | 1. Softcover reprint of the original 1st ed. 2015
Springer International Publishing (Verlag)
978-3-319-37894-7 (ISBN)

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The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.

Antipsychotics and the Dopamine-Serotonin Connection.- GLYT1 Inhibitors: From Hits to Clinical Candidates.- Metabotropic Glutamate Receptor 2 Activators.- Activation of the mGlu₅ Receptor for the Treatment of Schizophrenia and Cognitive-Deficit-Associated Disorders.- Muscarinic Acetylcholine Receptor Activators.- Nicotinic Acetylcholine Receptor Modulators.-The Use of PDE10A and PDE9 Inhibitors for Treating Schizophrenia.

From the book reviews:

"The target audience ... is primarily researchers in psychopharmacology involved in drug development. ... Each chapter concludes with citations of the pertinent scientific literature. This book covering small molecular therapeutics for schizophrenia would be a useful review for researchers studying this area." (Michael Joel Schrift, Doody's Book Reviews, March, 2015)

Erscheinungsdatum	29.08.2016
Reihe/Serie	Topics in Medicinal Chemistry
Zusatzinfo	VII, 323 p. 185 illus., 23 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
	Medizin / Pharmazie ► Pharmazie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Chemie ► Physikalische Chemie
Schlagworte	5HT Receptor Ligands • biochemistry • Chemistry and Materials Science • DA Receptor Ligands • GLYT1 Inhibitors • mACh Activators • medicinal chemistry • mGlu2 Activators • mGlu5 Positive Allosteric Modulators • nACh Activators • Neurosciences • PDE10/PDE9 Inhibitors • Psychopharmacology
ISBN-10	3-319-37894-5 / 3319378945
ISBN-13	978-3-319-37894-7 / 9783319378947
Zustand	Neuware