Introduction to Nanotheranostics (eBook)

Karthikeyan Narayanan, Subramanian Tamil Selvan (Autoren)

eBook Download: PDF

2016 | 1. Auflage
87 Seiten
Springer Singapore (Verlag)
978-981-10-1008-8 (ISBN)

Infos

This book offers readers an introduction to the current status of nanoparticles and other nanomaterials that have potential applications in theranostics. Above all, it highlights the diagnostic and therapeutic applications of metallic (e.g. Au, Ag), semiconducting quantum dots (e.g. CdSe, CdTe), magnetic (e.g. Fe3O4, FePt, Co), and multifunctional (combination of two or three) nanoparticles. 

Dr Subramanian Tamil Selvan is a Research Scientist at the A*STAR Institute of Materials Research and Engineering (IMRE) since September 2008. He also holds an Adjunct Associate Professorship with the Department of Bioengineering, National University of Singapore. Dr. Selvan is the recipient of the prestigious Alexander von Humboldt (Germany) and JSPS (Japan) fellowships. He serves as an Editorial Board Member of Scientific Reports. His research interests cover a broad spectrum which include the synthesis of metal, magnetic, semiconducting and multifunctional nanoparticles for energy and theranostics applications. He is an author of over 50 publications and 3 invited book chapters. He has over 2250 citations and a h-index of 22. To his credit, he has 2 granted U.S. patents and 10 filed patent applications.
Dr. Narayanan Karthikeyan is a Senior Research Scientist at the Institute of Bioengineering and Nanotechnology since 2006. He worked in Taiwan and USA before his current appointment at the Institute of Bioengineering and Nanotechnology. His research interests are in the area of Cell and Tissue Engineering, specifically on stem cell differentiation and large scale expansion of stem cells for therapeutic use; and drug and gene delivery systems for therapeutic and imaging various pathological conditions.  He is an author of over 30 publications and holds 3 patents.

Inhalt

Contents 6
Introduction 8
1 Introduction to Nanotheranostics 9
Abstract 9
1.1 Nanoparticles in General 9
1.1.1 Types of Nanoparticles 9
1.1.2 Importance of Coating or Surface Functionalization for Cellular Internalization 10
References 13
2 Metallic Nanoparticles for Theranostics 15
Abstract 15
2.1 Shape-Controlled Synthesis of Silver and Gold Nanoparticles 15
2.2 Antimicrobial Silver Nanoparticles 17
2.3 Gold Nanoparticles for SERS Detection and Drug Delivery 19
2.4 Effects of Surface Functionalization of Au NPs on Cell Delivery 20
2.4.1 Au–Herceptin Nanoclusters for Nuclear Targeting and Cancer Therapy 21
2.4.2 Au–Peptide NPs as Drug Delivery Vehicles 22
2.5 Silver Nanoparticles for Photo-Activated Gene Silencing 25
References 27
3 Semiconducting Nanoparticles or Quantum Dots for Theranostics 29
Abstract 29
3.1 Synthesis and Preparation 29
3.2 Applications of QDs 30
3.2.1 Intracellular Delivery of QDs 31
3.2.2 In Vivo Imaging with QDs 32
References 36
4 Magnetic Nanoparticles 39
Abstract 39
4.1 Introduction 39
4.2 Synthesis of MNPs 41
4.2.1 Co-precipitation 41
4.2.2 Micro-emulsions 43
4.2.3 Spray Pyrolysis 43
4.2.4 Polyols 43
4.2.5 Thermal Decomposition 44
4.2.6 Chemical Vapour and Plasma Assisted Synthesis 44
4.3 Stabilization of Magnetic Nanoparticles 45
4.3.1 Oxidation 45
4.3.2 Surfactant and Polymer Coating 46
4.3.3 Coating with Precious Metals 47
4.3.4 Silica Coating 47
4.3.5 Carbon Based Coating 49
4.3.6 Composites 51
4.4 Functionalization of the MNPs 56
4.5 Applications of MNPs 58
4.5.1 Non-biomedical Applications 58
4.5.2 Biomedical Applications 59
4.5.2.1 Gene Delivery in Cells Using MNPs 60
4.5.2.2 Drug Delivery 61
4.5.2.3 Magnetic Particles for Hyperthermia 62
4.5.2.4 Bio-imaging 65
References 67
5 Multifunctional Nanoparticles 77
Abstract 77
5.1 Other Nanoparticles for Nanotheranostics 79
5.2 Conclusions and Outlook 80
References 85

Produkt-Details

• Erscheint lt. Verlag: 15.6.2016
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Pflege
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie
• Themenwelt: Technik ► Maschinenbau
• ISBN-10: 981-10-1008-0 / 9811010080
• ISBN-13: 978-981-10-1008-8 / 9789811010088