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Cardiomyocytes – Active Players in Cardiac Disease

Klaus-Dieter Schlüter (Herausgeber)

Buch | Hardcover

XV, 278 Seiten

2016 | 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-31249-1 (ISBN)

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This book summarizes ourcurrent understanding about the biology and patho-biology of cardiomyocytes anddepicts common techniques for the study of these cells. Thebook is divided into two parts; the first part provides insight into role andfunction of cardiomyocytes under normal conditions and describes embryogenesisand differentiation, in the second part the role of cardiomyocytes in aging anddisease is discussed and cellular responses under stress conditions illustrated.Cardiomyocytes representthe main mass of the heart, and cellular malfunction directly modifies heartfunction leading to subsequent heart failure. As such, cardiomyocytes arecausative involved in the main reasons of heart failure, such as post-infarctremodeling, hypertensive heart disease, idiopathic heart failure, andinteractions with other co-morbidities such as diabetes. On the other hand,cardiomyocytes are necessarily target of therapy. Therefore, a preciseunderstanding of cardiomyocytes biology is a pre-requisite for proper diseasetreatment and evidence based medicine.

The book is written forcell biologists, pharmacologists and biomedical researchers specialized incardiac and vascular biology.

Prof. Dr. Klaus-Dieter Schlüter Institute of Physiology JLU Giessen Giessen, Germany

Cardiomyocytes: Function and Regeneration.- 1.Ways to study the biology of cardiomyocytes.-2.Cardiomyocytes: Function and Regeneration.- 3.Excitation-contraction couplingof cardiomyocytes.- 4.Cardiac metabolism and energetic control.- 5.Endogenousmechanisms for regulating myocardial contractility.- Cardiomyocytes in ageing,disease, and protection.- 6.Growth regulation of cardiomyocytes: Control ofcell size and its role in cardiac hypertrophy.- 7.Protein Degradation inCardiomyocytes - Target Proteins and clinical consequences.- 8.Ischemia andReperfusion.- 9.Mechanisms of cardiac cell death.- 10.Oxidative stress andnitrosative stress.

Erscheinungsdatum	08.10.2016
Zusatzinfo	XV, 278 p. 40 illus., 13 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Themenwelt	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Biomedical and Life Sciences • cardiac protection • cardiac remodelling • Cardiology • Cell Biology • excitation-contraction coupling • Human Physiology • Hypertrophy • Pharmaceutical Sciences/Technology • self renewing capacity
ISBN-10	3-319-31249-9 / 3319312499
ISBN-13	978-3-319-31249-1 / 9783319312491
Zustand	Neuware