Cardiomyocytes – Active Players in Cardiac Disease (eBook)

Klaus-Dieter Schlüter (Herausgeber)

eBook Download: PDF

2016 | 1st ed. 2016
XV, 278 Seiten
Springer International Publishing (Verlag)
978-3-319-31251-4 (ISBN)

Infos

This book summarizes our current understanding about the biology and patho-biology of cardiomyocytes and depicts common techniques for the study of these cells. The book is divided into two parts; the first part provides insight into role and function of cardiomyocytes under normal conditions and describes embryogenesis and differentiation, in the second part the role of cardiomyocytes in aging and disease is discussed and cellular responses under stress conditions illustrated. Cardiomyocytes represent the main mass of the heart, and cellular malfunction directly modifies heart function leading to subsequent heart failure. As such, cardiomyocytes are causative involved in the main reasons of heart failure, such as post-infarct remodeling, hypertensive heart disease, idiopathic heart failure, and interactions with other co-morbidities such as diabetes. On the other hand, cardiomyocytes are necessarily target of therapy. Therefore, a precise understanding of cardiomyocytes biology is a pre-requisite for proper disease treatment and evidence based medicine.

The book is written for cell biologists, pharmacologists and biomedical researchers specialized in cardiac and vascular biology.

 

Prof. Dr. Klaus-Dieter Schlüter Institute of Physiology JLU Giessen Giessen, Germany

Inhalt

Cardiomyocytes: Function and Regeneration.-  1.Ways to study the biology of cardiomyocytes.-
2.Cardiomyocytes: Function and Regeneration.- 3.Excitation-contraction coupling
of cardiomyocytes.- 4.Cardiac metabolism and energetic control.- 5.Endogenous
mechanisms for regulating myocardial contractility.- Cardiomyocytes in ageing,
disease, and protection.- 6.Growth regulation of cardiomyocytes: Control of
cell size and its role in cardiac hypertrophy.- 7.Protein Degradation in
Cardiomyocytes – Target Proteins and clinical consequences.- 8.Ischemia and
Reperfusion.- 9.Mechanisms of cardiac cell death.- 10.Oxidative stress and
nitrosative stress.

Produkt-Details

• Erscheint lt. Verlag: 28.6.2016
• Zusatzinfo: XV, 278 p. 40 illus., 13 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• Schlagworte: cardiac protection • cardiac remodelling • excitation-contraction coupling • Hypertrophy • self renewing capacity
• ISBN-10: 3-319-31251-0 / 3319312510
• ISBN-13: 978-3-319-31251-4 / 9783319312514