Concepts and Models for Drug Permeability Studies (eBook)

Cell and Tissue based In Vitro Culture Models

Bruno Sarmento (Autor)

eBook Download: PDF | EPUB

2015 | 1. Auflage
408 Seiten
Elsevier Science (Verlag)
978-0-08-100114-1 (ISBN)

Infos

This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route. - Updated information regarding the most recent in vitro models to study the permeability of drugs - Short and concise chapters covering all the biological barriers with interest in drug permeability - A combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models - Simple and clear scientific content, adaptable for young scientists and experimented researchers

BBruno Sarmento is Principal Investigator and Group Leader at Institute for Research and Innovation in Health (i3S), University of Porto (UP), and Invited Associate Professor at Instituto Universitário de Ciências da Saúde (IUCS), Portugal. His research is focused on the development of mucosal tissue engineering models to validate functionalized nanomedicines and to perform in vitro/in vivo correlation. He has also established functionalized nanomedicines for mucosal drug delivery of drug with poor mucosal bioavailability. He published more than 400 papers in international journals, most in top journals (20000 Scopus citations; H-index 73). He edited 5 books, participated in more than 50 invited/selected talks in national and international meetings and was awarded several distinctions. He has supervised/co-supervised 15 Post-Docs, 50 PhD students and 40 MSc students. He is editor of European Journal of Pharmaceutical Sciences, and member of the Editorial Advisory Board of several international journals, including the Journal of Controlled Release, Expert Opinion on Drug Delivery and Pharmaceutics. Bruno Sarmento was the first Chair of the Nanomedicine and Nanoscale Delivery Focus Group of the Controlled Release Society (CRS) and is now Director-at-Large of CRS and member of CRS College of Fellows.

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List of contributors

João Albuquerque,     University of Porto, Porto, Portugal

Isabel Almeida,     University of Porto, Porto, Portugal

Fernanda Andrade

Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Porto, Portugal

Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain

Francisca Araújo

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

ICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal

Marival Bermejo Sanz,     Universidad Miguel Hernández, San Juan de Alicante, Alicante, España

Malgorzata Burek,     Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany

Miguel Ángel Cabrera Pérez

Universidad Central Marta Abreu de Las Villas, Santa Clara, Villa Clara, Cuba

Universidad Miguel Hernández, San Juan de Alicante, Alicante, España

Pedro Castro,     CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal

Luise Chaves,     UCIBIO/REQUIMTE—Laboratory of Applied Chemistry, University of Porto, Porto, Portugal

João Coentro

INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

Faculdade de Engenharia da Universidade do Porto (FEUP), Porto, Portugal

Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal

Ana Costa

Instituto de Engenharia Biomédica (INEB), University of Porto, Porto, Portugal

CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra PRD, Portugal

Joana Costa

INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

FEUP—Faculdade de Engenharia da Universidade do Porto, Porto, Portugal

Paulo Costa,     University of Porto, Porto, Portugal

Sara Baptista da Silva

Faculty of Pharmacy, University of Porto, Porto, Portugal

CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal

José das Neves

INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

Tiago dos Santos,     INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

Domingos Ferreira,     Faculty of Pharmacy, University of Porto, Porto, Portugal

Carola Y. Förster,     Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany

Isabel González Álvarez,     Universidad Miguel Hernández, San Juan de Alicante, Alicante, España

Marta González-Álvarez,     Universidad Miguel Hernández, San Juan de Alicante, Alicante, España

Luís Gouveia,     iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal

Pedro L. Granja

INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

Faculdade de Engenharia da Universidade do Porto (FEUP), Porto, Portugal

Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal

Jouni Hirvonen,     Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Maria João Gomes

INEB—Instituto de Engenharia Biomédica, Universisdade do Porto, Porto, Portugal

ICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal

Instituto de Investigação e Inovação em Saude, Universidade do Porto, Porto, Portugal

Christian Kölln,     Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Braunschweig, Germany

Bianca N. Lourenço

INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

Faculdade de Engenharia da Universidade do Porto (FEUP), Porto, Portugal

Alexandra Machado

INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

Raquel Madureira,     CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal

Victor Mangas Sanjuan,     Universidad Miguel Hernández, San Juan de Alicante, Alicante, España

Sara Marques,     CIBIO/InBIO-UP—Centro de Investigação em Biodiversidade e Recursos Genéticos, University of Porto, Campus Agrário, Vairão, Portugal

Susana Martins,     University of Southern Denmark, Odense, Denmark

Bárbara Mendes

INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

Instituto de Investigação e Inovação em Saude, Universidade do Porto, Porto, Portugal

José Augusto Guimarães Morais,     iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal

Rute Nunes,     INEB—Instituto de Engenharia Biomédica, University of Porto, Porto, Portugal

Maria Beatriz P.P. Oliveira,     Requimte, Faculty of Pharmacy, University of Porto, Porto, Portugal

Paulo Paixão,     iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal

Carla Pereira

INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

FEUP—Faculdade de Engenharia da Universidade do Porto, Porto, Portugal

Manuela Pintado,     CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal

Stephan Reichl,     Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Braunschweig, Germany

Francisca Rodrigues

Requimte, Faculty of Pharmacy, University of Porto, Porto, Portugal

Fourmag Lda, Parque Industrial do Cruzeiro, Moreira de Cónegos, Portugal

Ellaine Salvador,     Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany

Hélder A. Santos,     Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Bruno Sarmento

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Superior de Ciências da Saúde-Norte, Departamento de Ciências Farmacêuticas, Gandra-PRD, Portugal

Neha Shrestha,     Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Cátia Silva,     CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra PRD, Portugal

Nuno Silva,     iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal

Nataša Škalko-Basnet,     University of Tromsø The Arctic University of Norway, Tromsø, Norway

Alejandro Sosnik,     Technion-Israel Institute of Technology, Technion City, Haifa, Israel

Flávia Sousa,     CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Superior de Ciências da Saúde-Norte, Gandra PRD, Portugal

Ingunn Tho,     University of Oslo, Oslo, Norway

Ana Vanessa Nascimento

University of Porto, Porto, Portugal

IINFACTS, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, CESPU, Cooperativa...

Produkt-Details

• Erscheint lt. Verlag: 30.9.2015
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• ISBN-10: 0-08-100114-2 / 0081001142
• ISBN-13: 978-0-08-100114-1 / 9780081001141