Epigenetic Cancer Therapy (eBook)

Steven Gray (Herausgeber)

eBook Download: PDF | EPUB

2015 | 1. Auflage
748 Seiten
Elsevier Science (Verlag)
978-0-12-800224-7 (ISBN)

Infos

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. - Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas - Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications - Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs

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List of Contributors

Bryce K. Allen,     Center for Therapeutic Innovation, The Miami Project to Cure Paralysis, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA

Donat Alpar,     Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK

Viren Amin,     Epigenome Center, Baylor College of Medicine, Houston, Texas, USA

Fazila Asmar,     Department of Hematology, Rigshospitalet, Copenhagen, Denmark

Nagi G. Ayad,     Center for Therapeutic Innovation, The Miami Project to Cure Paralysis, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA

Anne-Marie Baird

Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Queensland, Australia

Thoracic Oncology Research Group, Institute of Molecular Medicine, St. James’s Hospital, Dublin, Ireland

Louise J. Barber,     Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK

Becky A.S. Bibby,     Cancer Biology and Therapeutics Lab, School of Biological, Biomedical and Environmental Sciences, University of Hull, Yorkshire, UK

Emma Bolderson,     Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Queensland, Australia

Philippe Bouvet,     Laboratoire Joliot-Curie, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France

Frédéric Catez

Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France

Université de Lyon, Lyon, France

Leandro Cerchietti,     Hematology and Oncology Division, Medicine Department, Weill Cornell Medical College of Cornell University, New York, NY, USA

Snehajyoti Chatterjee

Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India

Laboratoire de Neurosciences Cognitives et Adaptatives, Université de Strasbourg-CNRS, GDR CNRS, Strasbourg, France

Taiping Chen

Department of Molecular Carcinogenesis and the Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Smithville, Texas, USA

The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA

Andreas I. Constantinou,     Laboratory of Cancer Biology and Chemoprevention, Department of Biological Sciences, School of Pure and Applied Sciences, University of Cyprus, Nicosia, Cyprus

Stuart J. Conway,     Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK

Dashyant Dhanak,     Janssen Research & Development, Spring House, PA, USA

Jean-Jacques Diaz

Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France

Université de Lyon, Lyon, France

Marc Diederich,     College of Pharmacy, Seoul National University, Gwanak-gu, Seoul, Korea

Xinmin Fan,     Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People’s Republic of China

Brendan Ffrench,     Department of Pathology, Coombe Women’s and Infant’s University Hospital, Dublin, Ireland

Michael F. Gallagher,     Department of Histopathology, University of Dublin, Trinity College, Trinity Centre, St James Hospital, Dublin, Ireland

Marco Gerlinger,     Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK

Steven D. Gore,     Department of Internal Medicine (Hematology), Yale Cancer Center, New Haven, CT, USA

Steven G. Gray

HOPE Directorate, St. James’s Hospital, Dublin, Ireland

Thoracic Oncology Research Group, Institute of Molecular Medicine, St. James’s Hospital, Dublin, Ireland

Kirsten Grønbæk,     Department of Hematology, Rigshospitalet, Copenhagen, Denmark

David S. Hewings,     Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK

Holger Heyn,     Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Catalonia, Spain

Zhe Jin

Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People’s Republic of China

Shenzhen Key Laboratory of Micromolecule Innovatal Drugs, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People’s Republic of China

Shenzhen Key Laboratory of Translational Medicine of Tumor, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People’s Republic of China

Stephanie Kaypee,     Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India

Yutaka Kondo,     Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya, Japan

Tapas K. Kundu,     Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India

Florian Laforêts

Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France

Université de Lyon, Lyon, France

Matthew W. Lawless,     Experimental Medicine, UCD School of Medicine and Medical Science, Mater Misericordiae University Hospital, Catherine McAuley Centre, Dublin, Ireland

Stephen G. Maher,     Cancer Biology and Therapeutics Lab, School of Biological, Biomedical and Environmental Sciences, University of Hull, Yorkshire, UK

Somnath Mandal

Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India

Department of Biochemistry, Faculty of Agriculture, Uttar Banga Krishi Viswavidyalaya, Pundibari, Cooch-Behar, West Bengal, India

Virginie Marcel

Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France

Université de Lyon, Lyon, France

Aleksandar Milosavljevic,     Epigenome Center, Baylor College of Medicine, Houston, Texas, USA

Hannah L. Moody

Cancer Biology and Therapeutics Lab, School of Biological, Biomedical and Environmental Sciences, University of Hull, Yorkshire, UK

Hull York Medical School, Yorkshire, UK

Atsushi Natsume,     Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

Thomas B. Nicholson,     Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, MA, USA

Kenneth J. O’Byrne

Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Queensland, Australia

Thoracic Oncology Research Group, Institute of Molecular Medicine, St. James’s Hospital, Dublin, Ireland

Shane O’Grady,     Experimental Medicine, UCD School of Medicine and Medical Science, Mater Misericordiae University Hospital, Catherine McAuley Centre, Dublin, Ireland

John J. O’Leary,     Department of Pathology, Coombe Women’s and Infant’s University Hospital, Dublin, Ireland

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Produkt-Details

• Erscheint lt. Verlag: 1.7.2015
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• ISBN-10: 0-12-800224-7 / 0128002247
• ISBN-13: 978-0-12-800224-7 / 9780128002247