Steroidal Activity in Experimental Animals and Man (eBook)

Ralph I. Dorfman (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
544 Seiten
Elsevier Science (Verlag)
978-1-4832-7299-3 (ISBN)

Infos

Methods in Hormone Research, Volume III: Steroidal Activity in Experimental Animals and Man, Part A focuses on protection against irradiation damage, anti-mammary tumor activity, body lipids, anti-aldosterone, central depressant action, and copulatory reflex activity. The selection first offers information on estrogens and anti-estrogens, including relative potencies in vaginal smear tests, vaginal tests, and uterine weight tests, mechanism of estrogen action, and mode action of anti-estrogens. The book then examines irradiation protection and anti-mammary tumor activities in rats and mice. The publication surveys steroids and lipid metabolism and the activities of adrenocorticosteroids in experimental animals and man. Discussions focus on adrenocortical, estrogenic, and androgenic and anabolic steroids; relative activities of corticosteroids assessed by laboratory and clinical methodology; and comparative efficacies of corticosteroids. The manuscript then ponders on anti-aldosterones, steroid central depressants, and copulatory reflex response to steroids. The selection is a vital source of data for readers interested in steroidal activity in man and animals.

Inhalt

Front Cover 1
Steroidal Activity in Experimental Animals and Man 4
Copyright Page 5
Table of Contents 10
CONTRIBUTORS TO VOLUME III 6
PREFACE 8
CONTENTS OF VOLUME I 12
CONTENTS OF VOLUME II 12
CONTENTS OF VOLUME IV 13
Chapter 1. 
14 
I. Types of Estrogen 14
II. 
18 
III. Relative Potencies in Other Vaginal Tests 35
IV. Relative Potencies in Uterine Weight Tests 38
V. Relative Potencies in Other Tests 46
VI. Relative Potencies in Man 53
VII. Interruption of Early Pregnancy 58
VIII. Investigations in Vitro 62
IX. Mechanism of Estrogen Action 65
REFERENCES 88
Chapter 2. 
94 
I. Types of Anti-Estrogens 94
II. Relative Potencies in Vaginal Smear Tests 96
III. Relative Potencies in Other Vaginal Tests 103
IV. Relative Potencies in Uterine Weight Tests 110
V. In Vitro Tests 120
VI. Other Activities 124
VII. Mode of Action of Anti-Estrogens 128
REFERENCES 136
Chapter 3. 
140 
I. Introduction 140
II· Corticoids 140
.II. Estrogens 143
IV· Androgens 146
V. Progestational Steroids 147
VI. Summary 149
REFERENCES 149
Chapter 4. 
152 
I. 
152 
II. Steroids Showing Activity Against Mouse Mammary Tumors 153
III. Steroids Showing Activity Against Rat Mammary Tumors 155
IV. Activity of Steroids Against a Spectrum of Rat and Mouse Mammary tumors 158
REFERENCES 195
Chapter 5. 
198 
I. Introduction 198
II. Adrenocortical Steroids 199
III. Estrogenic Steroids 211
IV. Androgenic and Anabolic Steroids 225
V. Progestational Steroids 229
VI. Steroid Inhibitors of Cholesterol Biosynthesis 229
ACKNOWLEDGMENT 233
REFERENCES 233
Chapter 6. Activities of Adrenocorticosteroids in Experimental Animals and Man 240
I. Introduction 240
II. Relative Activities of Corticosteroids Assessed by Laboratory and Clinical Methodology 241
III. Comparative Efficacies of Corticosteroids 306
REFERENCES 349
Chapter 7. 
364 
I. Introduction 364
II. Steroidal Spirolactones 366
III. Progesterone and Derivatives 407
IV. Testosterone and Derivatives 414
V· Corticoids 416
VI. Estrogenic Steroids 417
REFERENCES 417
Chapter 8. 
428 
I. Introduction 428
II. Relationship of Steroid Structure to Anesthetic Activity 429
III. Pharmacology of Hydroxydione 460
REFERENCES 482
Chapter 9. 
490 
I. Introduction 490
II. Response to Progestational Compounds 491
III. Response to Nonprogestational Steroids 494
IV. Relation Between Copulatory Reflex Activity and Progestational Activity 495
V. Summary 496
REFERENCES 496
Author Index 498
Subject Index 531

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• ISBN-10: 1-4832-7299-0 / 1483272990
• ISBN-13: 978-1-4832-7299-3 / 9781483272993