Hormones and the Aging Process (eBook)

Proceedings of a Conference Held at Arden House, Harriman, New York, 1955

Earl T. Engle, Gregory Pincus (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
336 Seiten
Elsevier Science (Verlag)
978-1-4832-7287-0 (ISBN)

Infos

Hormones and the Aging Process covers the proceedings of the conference held at Arden House in Harriman, New York on the role of hormones in aging. The book focuses on the influence of hormones to the aging process, including steroid metabolism, castration, and hormonal regulation. The selection first offers information on the effect of aging on steroid metabolism as reflected in plasma levels; role of thyroid in the aging process; and urinary excretion of gonadotropin as a function of age. The book also takes a look at hormonal regulation of muscle development and steroids and protein metabolism in experimental animals. Discussions focus on the effects of castration, steroids in recovery from protein depletion, androgens and protein metabolism, and protein nutrition and hormone action. The publication examines the androgenic and anabolic action of testosterone derivatives and the effects of hormones on protein metabolism, including growth and thyroid hormones, testosterone, insulin, and adrenal cortical steroids. The book also ponders on the role of steroids in calcium and phosphorus metabolism; mechanisms regulating fluid and electrolyte metabolism; and sex steroid replacement in aging individuals. The selection is a dependable reference for readers interested in the relationship of hormones and the aging process.

Inhalt

Front Cover 1
Hormones and the Aging Process 4
Copyright Page 5
Table of Contents 10
PARTICIPANTS 6
PREFACE 8
Chapter 1. 
14 
I. THE MEASUREMENT OF URINARY STEROID MIXTURES 14
II. MEASUREMENTS O F INDIVIDUAL URINARY STEROIDS 17
III. THE EFFECTS OF STRESS 24
REFERENCES 32
DISCUSSION 32
Chapter 2. 
34 
I. 17-HYDROXYCORTICOSTEROIDS 35
II. 17-KETOSTEROIDS 42
III. SUMMARY 44
REFERENCES 45
DISCUSSION 46
Chapter 3. 
52 
REFERENCES 57
DISCUSSION 57
Chapter 4. 
62 
I. MATERIAL AND METHODS 62
II. RESULTS 63
III. SUMMARY 71
REFERENCES 71
DISCUSSION 71
Chapter 5. 
76 
PROCEDURE 76
RESULTS 77
EFFECT OF CASTRATION 78
THE EFFECT OF AGE AND CASTRATION ON THE "TOTAL" SKELETAL MUSCLE MASS 83
COMPARISON OF THE EFFECT OF VARIOUS STEROIDS 83
SUMMARY 84
REFERENCES 87
DISCUSSION 87
Chapter 6. 
92 
I. ANDROGENS AND PROTEIN METABOLISM 93
II. ESTROGENS AND PROTEIN METABOLISM 93
III. STEROIDS IN RECOVERY FROM PROTEIN DEPLETION 96
IV. HYPOPHYSECTOMY AND PROTEIN REPLETION 98
V. AGING, HORMONES, AND PROTEIN METABOLISM 98
VI. PROTEIN NUTRITION AND HORMONE ACTION 102
VII. CONCLUSIONS 103
REFERENCES 103
DISCUSSION 104
Chapter 7. 
112 
I. ANABOLIC-ANDROGENIC RATIO 113
II. 19-NORTESTOSTERONE 113
III. DERIVATIVES OF 19-NORTESTOSTERONE 114
IV. DISCUSSION 121
V. SUMMARY 123
REFERENCES 124
DISCUSSION 125
Chapter 8. 
128 
I. OBSERVATIONS 128
II. DISCUSSION 130
REFERENCES 133
DISCUSSION 134
Chapter 9. 
140 
I. TESTOSTERONE 142
II. THYROID HORMONE 143
III. GROWTH HORMONE 144
III. INSULIN 147
IV. ADRENAL CORTICAL STEROIDS 150
V. CONCLUDING COMMENT 157
REFERENCES 158
Chapter 10. 
160 
I. OÖPHORECTOMY 161
II. ADRENALECTOMY 168
III. HYPOPHYSECTOMY 168
IV. CORTISONE 172
V. ANDROGEN 178
VI. SUMMARY 181
DISCUSSION 183
Chapter 11. 
188 
I. CALCIUM TOLERANCE TEST 192
II. EFFECT OF CHELATING AGENTS UPON CALCIUM METABOLISM 198
III. CA45 METABOLISM IN MAN 204
REFERENCES 210
DISCUSSION 210
Chapter 12. 
214 
REFERENCES 229
DISCUSSION 230
Chapter 13. 
234 
COMBINED GONADAL THERAPY 240
OPTIMAL DOSE OF ANDROGENS, ESTROGENS 240
UNDESIRABLE SIDE EFFECTS 241
ORAL PREPARATIONS 242
UTERINE BLEEDING 243
CARCINOGENESIS 244
DIETARY CALCIUM AND PHOSPHORUS 244
VITAMIN D 245
VALUE OF STRONTIUM SALTS 245
SUMMARY 248
REFERENCES 249
DISCUSSION 250
Chapter 14. 
254 
REFERENCES 260
DISCUSSION 261
Chapter 15. 
266 
I. INTERPRETATION OF BIOCHEMICAL DATA IN BREAST CANCER 267
II. HORMONAL FACTORS IN BREAST CANCER 270
CONCLUSION 281
REFERENCES 283
DISCUSSION 283
Chapter 16. 
286 
I. INTRODUCTION 286
II. CHANGES IN THE PROSTATE WITH AGE 287
III. THE ROLE OF THE TESTIS 288
IV. ESTROGENS OF THE TESTIS 290
V. THE ADRENAL CORTEX 290
VI. THE ANTERIOR PITUITARY 291
VII. NUTRITIONAL ASPECTS OF ENDOCRINE UTILIZATION 292
VIII. PROSTATIC ENZYMES 292
REFERENCES 293
DISCUSSION 294
Chapter 17. 
296 
I. DIET AS AN ANABOLIC STIMULUS 297
II. METABOLIC EFFECTS FOR THE ORAL ADMINISTRATION OF STILBESTROL 299
III. METABOLIC EFFECTS OF STANOLONE 302
REFERENCES 309
DISCUSSION 310
Chapter 18. 
312 
I. CHOICE OF METHODS 312
II. CHOICE OF SUBJECTS 313
III. PROCEDURE 314
REFERENCES 320
DISCUSSION 321
Author Index 324
Subject Index 332

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• ISBN-10: 1-4832-7287-7 / 1483272877
• ISBN-13: 978-1-4832-7287-0 / 9781483272870