Fc Receptors (eBook)

Marc Daeron, Falk Nimmerjahn (Herausgeber)

eBook Download: PDF

2014 | 2014
XV, 424 Seiten
Springer International Publishing (Verlag)
978-3-319-07911-0 (ISBN)

Infos

This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.

Inhalt

Part I : Old and new FcRs  Hiromi Kubagawa, Yoshiki Kubagawa, Dewitt Jones, Tahseen H. Nasti, Mark Walter, and Kazuhito HonjoThe Old but New IgM Fc Receptor (FcμR) F.J. Li, W.J. Won, E.J. Becker Jr., J.L. Easlick, E. Tabengwa, R. Li, M. Shakhmatov, P.D. Burrows, and R.S. DavisEmerging Roles for FCRL Family Members in Lymphocyte Biology and Disease Leo C. JamesIntracellular antibody immunity and the cytosolic Fc receptor TRIM21  Part II: FcR signaling Anna Niarakis, Yacine Bounab, Luca Grieco, Roman Roncagalli, Jérôme Garin, Bernard Malissen, Marc Daëron, Denis ThieffryComputational modeling of the main signaling pathways involved in mast cell activation Tarik Attout, Andres Floto and Pierre LaunayCalcium channels in FcR signaling Marcel Kuhny, Carolin N. Zorn, and Michael HuberRegulation of FcεRI signaling by lipid phosphatases  Part III: FcR biology Marc DaëronFc Receptors as Adaptive Immunoreceptors Jerrard M Hayes, Eoin FJ Cosgrave, Weston B Struwe, Mark Wormald, Gavin P. Davey, Roy Jefferis, Pauline M RuddGlycosylation and Fc Receptors Birgitta HeymanAntibodies as natural adjuvants Sanae Ben Mkaddem, Ivy Christou, Elisabetta Rossato, Laureline Berthelot, Agnès Lehuen and Renato C. MonteiroIgA, IgA receptors and their anti-inflammatory properties Stylianos Bournazos, David J. DiLillo and Jeffrey V. RavetchHumanized mice to study FcγR function Dilip K. Challa, Ramraj Velmurugan, Raimund J. Ober and E. Sally WardFcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions.  Part IV: FcRs and disease Xinrui Li, Andrew W Gibson and Robert P KimberlyHuman FcR polymorphism and disease. Hanane el Bannoudi, Andreea Ioan-Facsinay and René E. M. ToesBridging auto-antibodies and arthritis; the role of Fc Receptors P. Mark Hogarth, Jessica C. Anania, Bruce D. WinesThe FcγR of humans and non-human primates and their interaction with IgG:  Implications for induction of inflammation, resistance to infection and the use of therapeutic monoclonal antibodies  Part V: FcRs and therapeutic antibodies Ann L White, Stephen A Beers and Mark S. CraggFcgRIIB as a key determinant of agonistic antibody efficacy                Jantine E. Bakema and Marjolein van EgmondFc receptor dependent mechanisms of monoclonal antibody therapy of cancer; professionals at work Sybille Böhm, Daniela Kao and Falk NimmerjahnSweet and Sour: The role of glycosylation for the anti-inflammatory activity of immunoglobulin G

Produkt-Details

• Erscheint lt. Verlag: 12.8.2014
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Zusatzinfo: XV, 424 p. 55 illus., 44 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Agonist antibodies • calcium channels • FcR • Fc receptors • FcR signaling • Glycosylation • Humanized mice • Lipid phosphatases • receptors • Rheumatoid Arthritis
• ISBN-10: 3-319-07911-5 / 3319079115
• ISBN-13: 978-3-319-07911-0 / 9783319079110