Current Advances in Osteosarcoma (eBook)

M.D. Kleinerman Eugenie S. (Herausgeber)

eBook Download: PDF

2014 | 2014
XII, 359 Seiten
Springer International Publishing (Verlag)
978-3-319-04843-7 (ISBN)

Infos

Current Advances in Osteosarcoma edited by Dr. Eugenie S. Kleinerman summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer. It accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. To improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. Current Advances in Osteosarcoma summarizes all of these new discoveries in one singular text, which will help move the field forward.

Eugenie S. Kleinerman, M.D. is Professor and Head of the Division of Pediatrics, the first women Division Head at MD Anderson Cancer Center. She is board certified in pediatrics, holds the Mosbacher Pediatrics Chair and is also a Professor of Cancer Biology. Dr. Kleinerman is internationally recognized for her scientific and clinical expertise in sarcomas, particularly osteosarcoma. She pioneered the use of a unique immunotherapy agent liposome-encapsulated MTP-PE, for children with unresponsive relapsed osteosarcoma lung metastases. Dr. Kleinerman has served on numerous NCI study sections and was a prior member of an FDA advisory panel. She has authored over 177 articles and 21 book chapters and has received over 2900 citations. In 2006, her achievements were recognized by her alma mater, Duke University Medical Center, where she received the Distinguished Medical Alumnus Award. She is the 2009 recipient of the Faculty Achievement Award in Clinical Research.

Inhalt

Historical Perspective on the Introduction and Use of Chemotherapy for the Treatment of OsteosarcomaNorman JaffeWnt Signaling in OsteosarcomaCarol H Lin, Tao Ji, Cheng-Fong Chen, Bang H HoangReceptor Tyrosine Kinases in Osteosarcoma: Not Just the Usual SuspectsAshley N. Rettew, Patrick J Getty, and Edward M. GreenbergUnderstanding the Role of Notch in OsteosarcomaMadonna M McManus, Kurt R Weiss, and Dennis PM Hughes Developmental Pathways Highjacked by OsteosarcomaYi Zhang, Jared R Mortus, and Dennis PM Hughes MicroRNAs in OsteosarcomagenesisLisa A Kafchinski and Kevin B JonesRECQ DNA Helicases and OsteosarcomaLinchao Lu, Weidong Jin, Hao Liu, and Lisa L Wang Autophagy in OsteosarcomaJanice Santiago O’Farrill and Nancy GordonHER-2 Involvement in OsteosarcomaJonathan Gill, David Geller, and Richard GorlickRole of Ezrin in Osteosarcoma MetastasisLing Ren and Chand KhannaParticipation of the Fas/FasL Signaling Pathway and the Lung Microenvironment in the Development of Osteosarcoma Lung MetastasesGangxiong Huang, Kazumasa Nishimoto, Yuanzheng Yang, and Eugenie S Kleinerman Zebrafish as a Model for Human OsteosarcomaAB Mohseny and Pancras CW HogendoornUsing Canine Osteosarcoma as a Model to Assess Efficacy of Novel Therapies: Can Old Dogs Teach Us New Tricks?Carlos O RodriguezOncolytic Viruses for Potential Osteosarcoma TherapyPooja Hingorani, Valerie Sampson, Christina Lettieri, E. Anders KolbIL-11Rα: A Novel Target for the Treatment of OsteosarcomaValerae LewisBone-seeking Radiopharmaceuticals as Targeted Agents of Osteosarcoma: Samarium-153-EDTMP and Radium-223Peter M Anderson, Vivek Subbiah, and Eric RohrenMuramyl Tripeptide-phophatidyl Ethanolamine Encapsulated in Lipomes (L-MTP-PE) in the Treatment of OsteosarcomaPaul A MeyersGenetically Modified T-cell Therapy for OsteosarcomaChristopher DeRenzo and Stephen GottschalkNatural Killer Cells for OsteosarcomaNidale Tarek, and Dean A Lee.

Produkt-Details

• Erscheint lt. Verlag: 12.6.2014
• Reihe/Serie: Advances in Experimental Medicine and Biology
• Reihe/Serie: Advances in Experimental Medicine and Biology
• Zusatzinfo: XII, 359 p. 65 illus., 54 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pädiatrie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Bone Cancer • Cancer • Metastasis • osteosarcoma • Pediatric Cancer
• ISBN-10: 3-319-04843-0 / 3319048430
• ISBN-13: 978-3-319-04843-7 / 9783319048437