Microbial Biochemistry (eBook)

G. N. Cohen (Autor)

eBook Download: PDF

2014 | 3rd ed. 2014
XXVIII, 611 Seiten
Springer Netherland (Verlag)
978-94-017-8908-0 (ISBN)

Infos

Microbial physiology, biochemistry and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle.

Inhalt

ForewordIntroduction1.       Bacterial growth2.       The outer membrane of Gram-negative bacteria and the cytoplasmic membrane3.       Peptidoglycan synthesis and cell division4.       Cellular permeability5.       Allosteric enzymes6.       Glycolysis, gluconeogenesis, glycogen and cellulose biosynthesis7.       The pentose phosphate and Entner-Doudoroff pathways8.       The tricarboxylic acid cycle and the glyoxylate bypass9.       ATP-generating processes. Respiration and Fermentation10.   Biosynthesis of lipids11.   Iron-sulfur proteins12.   The Archaea13.   Methanogens and methylotrophs14.   Enzyme induction in catabolic systems15.   Transcription. RNA polymerase16.   Negative regulation17.   Enzyme repression in anabolic pathways18.   Positive regulation19.   The Ribosomes, Translation, Chaperones and Chaperonins20.   The genetic code, the transfer RNAs and the aminoacyl-tRNA-synthetases21.   Attenuation22.   Regulation by RNAs and Riboswitches 23.   The biological fixation of nitrogen 24.   How biosynthetic pathways have been established 25.   The aspartic acid family of amino acids26.   Regulation of the biosynthesis of the amino acids of the aspartic acid family in Enterobacteriaceae27.   Other patterns of regulation of the synthesis of amino acids of the aspartate family28.   Biosynthesis of the amino acids of the glutamic acid family and its regulation29.   Biosynthesis of amino acids derived from phosphoglyceric acid and pyruvic acid30.   Selenocysteine and selenoproteins31.   Biosynthesis of aromatic amino acids and its regulation32.   The biosynthesis of histidine and its regulation33.   The biosynthesis of nucleotides34.   The biosynthesis of deoxyribonucleotides35.   Biosynthesis of some water-soluble vitamins and of their coenzyme forms36.   Biosynthesis of carotene, vitamin A, sterols, ubiquinones and menaquinones37.   Biosynthesis of the tetrapyrrole ring system38.   Biosynthesis of cobalamins including vitamin B1239.   Interactions between proteins and DNA40.   Evolution of biosynthetic pathwaysAbbreviationsSubject Index.

Produkt-Details

• Erscheint lt. Verlag: 21.7.2014
• Zusatzinfo: XXVIII, 611 p. 314 illus., 9 illus. in color.
• Verlagsort: Dordrecht
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Technik
• Schlagworte: biosynthetic pathways • Permeability • Regulation Archaea
• ISBN-10: 94-017-8908-8 / 9401789088
• ISBN-13: 978-94-017-8908-0 / 9789401789080