Central Functions of the Ghrelin Receptor (eBook)

Jeanelle Portelli, Ilse Smolders (Herausgeber)

eBook Download: PDF

2014 | 2014
XVII, 214 Seiten
Springer New York (Verlag)
978-1-4939-0823-3 (ISBN)

Infos

The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson's disease, epilepsy, anxiety and depression.

Inhalt

Part 1: The ghrelin receptor isoformsChapter 1: Constitutive activity of the ghrelin receptorJacek Mokrosiński, Andreas Nygaard Madsen, Birgitte HolstChapter 2: Homodimerization and heterodimerization of the ghrelin receptorAlessandro Laviano, Alessia MariPart 2: Mechanisms of ghrelin’s actionChapter 3: The role of the ghrelin receptor in appetite and energy metabolismZane AndrewsChapter 4: The vagus nerve and ghrelin functionYukari DatePart 3: Ghrelin receptors in food and drug addictive mechanismsChapter 5: Central Ghrelin Receptors and Food IntakeMario Perello, Jesica RaingoChapter 6: Ghrelin receptors a novel target for obesityHarriët Schellekens, Timothy G. Dinan, John F. CryanChapter 7: Ghrelin receptor antagonism as a potential therapeutic target for alcohol use disorders: a preclinical perspectiveElisabet Jerlhag, Jörgen A. EngelChapter 8: Clinical Research on the Ghrelin Axis and Alcohol ConsumptionAllison A. Feduccia, Lorenzo Leggio Part 4: Ghrelin plays a role in various physiological and pathophysiological brain functionsChapter 9: Ghrelin and Sleep RegulationÉva Szentirmai, Levente KapásChapter 10: Ghrelin and MemoryNicolas Kunath, Martin DreslerChapter 11: Ghrelin receptors and Epilepsy Jeanelle Portelli, Ann Massie, Jessica Coppens, Ilse SmoldersChapter 12: Ghrelin plays a role in various physiological and pathophysiological brain functionsSarah J. SpencerChapter 13: Ghrelin and Parkinson’s DiseaseMarcus M. Unger, Wolfgang H. Oertel

Produkt-Details

• Erscheint lt. Verlag: 15.5.2014
• Reihe/Serie: The Receptors
• Reihe/Serie: The Receptors
• Zusatzinfo: XVII, 214 p. 12 illus., 7 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Schlagworte: addicton • constitutive receptor activity • food intake • ghrelin receptors • pathophysiology
• ISBN-10: 1-4939-0823-5 / 1493908235
• ISBN-13: 978-1-4939-0823-3 / 9781493908233