MACPF/CDC Proteins - Agents of Defence, Attack and Invasion
The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different super family members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.
Part I: Overview of MACPF/CDCs.- Introduction: Brief Historical Overview.- Distribution of MACPF/CDC proteins.- Evolution of the Complement System.- Part II: Structures of MACPF/CDCs.- Structural Features of Cholesterol Dependent Cytolysins and Comparison to other MACPF-domain containing proteins.- Perfringolysin O Structure and Mechanism of Pore Formation as a Paradigm for Cholesterol-Dependent Cytolysins.- Structural Biology of the Membrane Attack Complex.- Part III: Functional aspect.- Membrane Interactions and Cellular Effects of MACPF/CDC Proteins.- The Biology of Pneumolysin.- Multifaceted Activity of Listeriolysin O, the Cholesterol-Dependent Cytolysin of Listeria monocytogenes.- Perforin - a Key Pore-Forming Protein for Immune Control of Viruses and Cancer.- Perforin and Human Diseases.- The role of MACPF Proteins in the Biology of Malaria and other Apicomplexan Parasites.- Chlamydial MACPF Protein CT153.- Fungal MACPF-Like Proteins and Aegerolysins: Bi-Component Pore-Forming Proteins?.- Fluorescence Imaging of MACPF/CDC Proteins: New Techniques and Their Application.
Erscheint lt. Verlag | 19.5.2014 |
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Reihe/Serie | Subcellular Biochemistry ; 80 |
Zusatzinfo | 52 Illustrations, color; 5 Illustrations, black and white; XI, 329 p. 57 illus., 52 illus. in color. |
Verlagsort | Dordrecht |
Sprache | englisch |
Maße | 155 x 235 mm |
Themenwelt | Schulbuch / Wörterbuch |
Medizin / Pharmazie ► Pflege | |
Medizin / Pharmazie ► Studium | |
Naturwissenschaften ► Biologie ► Biochemie | |
Naturwissenschaften ► Biologie ► Zoologie | |
Naturwissenschaften ► Chemie | |
Schlagworte | bacterial pathogenesis • biophysical approaches • immunity • MACPF/CDC superfamily • pore forming proteins |
ISBN-10 | 94-017-8880-4 / 9401788804 |
ISBN-13 | 978-94-017-8880-9 / 9789401788809 |
Zustand | Neuware |
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