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Trichloroethylene: Toxicity and Health Risks

Kathleen M. Gilbert, Sarah J. Blossom (Herausgeber)

Buch | Hardcover

245 Seiten

2014
Springer London Ltd (Verlag)
978-1-4471-6310-7 (ISBN)

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A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity.

History of TCE.- Trichloroethylene and autoimmunity in human and animal.-Hypersensitivity Dermatitis and Hepatitis.- Trichloroethylene-induced oxidative stress and autoimmunity.-Brain and Behavioral Changes in Rodent Models.- Role of Trichloroethylene in Parkinson’s disease.- Neuroimmune effects of developmental TCE exposure.- Environmental sensitivity to trichloroethylene (TCE) in the developing heart.- Trichloroethylene and Cancer.- Epigenetic Alterations Due to Trichloroethylene.- Mathematical Modeling and Trichloroethylene

Erscheint lt. Verlag	7.3.2014
Reihe/Serie	Molecular and Integrative Toxicology
Zusatzinfo	13 Illustrations, color; 10 Illustrations, black and white; X, 245 p. 23 illus., 13 illus. in color.
Verlagsort	England
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Studium ► Querschnittsbereiche ► Klinische Umweltmedizin
	Naturwissenschaften ► Biologie ► Biochemie
Schlagworte	endocrine • epigenetic • Immunotoxicity • Nephrotoxicity • neurotoxicity • trichloroethylene
ISBN-10	1-4471-6310-9 / 1447163109
ISBN-13	978-1-4471-6310-7 / 9781447163107
Zustand	Neuware