Modulation of Presynaptic Calcium Channels (eBook)

Gary Stephens, Sumiko Mochida (Herausgeber)

eBook Download: PDF

2013 | 2013
XII, 365 Seiten
Springer Netherland (Verlag)
978-94-007-6334-0 (ISBN)

Infos

This book will bring together leading international experts to discuss recent advances in basic scientific knowledge regarding the regulation of presynaptic Ca2+ channels. Importantly, Ca2+ channels represent one of the most widely modulated proteins in the body, being the target of a range of effector pathways and drugs; this range will be fully represented here. A number of therapeutic drugs target the Ca2+ channel complex, including the anti-epileptic gabapentinoid and analgesic ziconotide drugs and the pharmaceutical industry is searching for Ca2+ channel blocking drugs, particularly in the pain, epilepsy, ataxia and migraine areas. Such potential future therapies will be discussed here. Scientific disciplines will focus on electrophysiological studies, but will extend to neuroscience, genetics and biochemical areas. The work described will represent advances at the cutting edge of current neuroscience research and is timely and highly appropriate for the Springer book series.

Inhalt

Foreword: Gary StephensOverview1. Spatial and temporal regulation of Ca2+ channels; Sumiko Mochida Interaction partners of calcium channels2. Neuronal functions of auxiliary calcium channel subunits; Gerald Obermair and Bernd Flucher 3. Reciprocal regulation of neuronal calcium channels by synaptic proteins; Norbert Weiss and Gerald Zamponi 4. Molecular architecture of Ca2+ channel complexes organized by β subunits in presynaptic active zones; Akito Nakao, Mitsuru Hirano, Yoshinori Takada, Shigeki Kiyonaka and Yasuo Mori 5. Control of CaV2 calcium channels and neurosecretion by heterotrimeric G protein coupled receptors; Mark L. Jewell and Kevin P.M. Currie 6. Regulation of CaV2 channels by small GTPases; Pierre Charnet, Frédérique Scamps, Matthieu Rousset, Claudine Menard, Michel Bellis and Thierry Cens 7. Protein interaction partners of Cav2.3 R-type voltage-gated calcium channels; Maxine Dibué, Etienne E. Tevoufouet, Andreas Krieger, Alexandra Kiel, Dimitar Evdokimov, Thomas Galetin, Serdar Alpdogan, Isha Akhtar, Sabrina Scharf, Renate Clemens, Kayalvizhi Radhakrishnan, Jürgen Hescheler, Toni Schneider, Marcel A. Kamp 8. Voltage-gated calcium channel signaling to the nucleus; Michel Bellis, Thierry Cens, Claudine Menard, Pierre Charnet and Matthieu Rousset Mechanisms of studying calcium channel effects9. Presynaptic Ca2+ influx and its modulation at auditory calyceal terminals; Holger Taschenberger, Kun-Han Lin and Shuwen Chang 10. Use of synthetic Ca2+ channel peptides to study presynaptic function; Giovanna Bucci, Sumiko Mochida and Gary Stephens Calcium channel therapeutics11. Impact of a loss-of-function P/Q type Ca2+ channel mutation on excitatory synaptic control of cerebellar Purkinje neurons; David Friel 12. CaV2.1 (P/Q) voltage activated Ca2+ channels and synaptic transmission in genetic and autoimmune diseases; Osvaldo Uchitel 13. Splicing and editing to customize CaV channel structures for optimal neural function; Hua Huang, Juejin Wang and Tuck Wah Soong14. Presynaptic calcium channels as drug targets for pain; Edward Stevens and Peter Fox15. Sensory pathway modulation by calcium channel a2d1 subunit; Chunyi Zhou and Z. David Luo Index

Produkt-Details

• Erscheint lt. Verlag: 23.4.2013
• Zusatzinfo: XII, 365 p.
• Verlagsort: Dordrecht
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• Schlagworte: calcium channels • CNS disease • Genetic Disease • presynaptic mechanisms • synaptic transmission
• ISBN-10: 94-007-6334-4 / 9400763344
• ISBN-13: 978-94-007-6334-0 / 9789400763340