Systems Biology in Drug Discovery and Development (eBook)

Daniel L. Young, Seth Michelson (Autoren)

eBook Download: PDF

2011 | 1. Auflage
376 Seiten
John Wiley & Sons (Verlag)
978-1-118-01641-1 (ISBN)

Infos

The first book to focus on comprehensive systems biology as applied
to drug discovery and development

Drawing on real-life examples, Systems Biology in Drug Discovery
and Development presents practical applications of systems biology
to the multiple phases of drug discovery and development. This book
explains how the integration of knowledge from multiple sources,
and the models that best represent that integration, inform the
drug research processes that are most relevant to the
pharmaceutical and biotechnology industries.

The first book to focus on comprehensive systems biology and its
applications in drug discovery and development, it offers
comprehensive and multidisciplinary coverage of all phases of
discovery and design, including target identification and
validation, lead identification and optimization, and clinical
trial design and execution, as well as the complementary systems
approaches that make these processes more efficient. It also
provides models for applying systems biology to pharmacokinetics,
pharmacodynamics, and candidate biomarker identification.

Introducing and explaining key methods and technical approaches
to the use of comprehensive systems biology on drug development,
the book addresses the challenges currently facing the
pharmaceutical industry. As a result, it is essential reading for
pharmaceutical and biotech scientists, pharmacologists,
computational modelers, bioinformaticians, and graduate students in
systems biology, pharmaceutical science, and other related
fields.

Autor

Daniel L. Young, PhD the Director of Computational Biosciences at Theranos Inc., where he leads the development of systems biology approaches to advance and enhance drug discovery and development and the optimal delivery of healthcare. He has written over twenty publications in the field of systems biology. Seth Michelson, PhD, is the Director of Nonclinical Biostatistics at Genomic Health, Inc. inventor or co-inventor for fourteen patent applications and one issued patent; and has contributed to over seventy publications.

Rezensionen

"I enjoyed reading this book as it should be essential
reading for those involved in drug discovery and development for
all others who share an interest in this field."
(International Society for the Study of Xenobiotics,
2012)

"In short, this is an indispensable tool for both experienced
and early stage investigators and others to understand the current
and future impact of systems biology on the drug discovery and
development process." (Doody's, 6 January 2012)

Produkt-Details

• Erscheint lt. Verlag: 9.9.2011
• Reihe/Serie: Wiley Series on Technologies for the Pharmaceutical
• Reihe/Serie: Wiley Series on Technologies for the Pharmaceutical
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Bioinformatics & Computational Biology • Bioinformatik • Bioinformatik u. Computersimulationen in der Biowissenschaften • Biowissenschaften • Chemie • Chemistry • Drug Discovery & Development • Life Sciences • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Pharmazeutische Chemie • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
• ISBN-10: 1-118-01641-6 / 1118016416
• ISBN-13: 978-1-118-01641-1 / 9781118016411