PEGylated Protein Drugs: Basic Science and Clinical Applications (eBook)

Francesco M. Veronese (Herausgeber)

eBook Download: PDF

2009 | 2009
IX, 290 Seiten
Springer Basel (Verlag)
978-3-7643-8679-5 (ISBN)

Infos

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

Inhalt

Preface PEGylated protein conjugates: A new class of therapeutics for the 21st century.- Protein PEGylation, basic science and biological applications.- Reactive PEGs for protein conjugation.- Rebridging disulphides: site-specific PEGylation by sequential bis-alkylation.- Enzymatic techniques for PEGylation of biopharmaceuticals.- The site-specific TGase-mediated PEGylation of proteins occurs at flexible sites.- Protein conjugates purification and characterization.- PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals.- The occurrence, induction, specificity and potential effect of antibodies against poly(ethylene glycol).- Pegfilgrastim — designing an improved form of rmetHuG-CSF.- PEGylation of human growth hormone: strategies and properties.- PEGylated ? interferons: two different strategies to achieve increased efficacy.- Development of PEGylated mammalian urate oxidase as a therapy for patients with refractory gout.- Certolizumab pegol: a PEGylated anti-tumour necrosis factor alpha biological agent.- PEG: a useful technology in anticancer therapy.- Regulatory strategy and approval processes considered for PEG-drug conjugates and other nanomedicines.

Produkt-Details

• Erscheint lt. Verlag: 30.12.2009
• Reihe/Serie: Milestones in Drug Therapy
• Reihe/Serie: Milestones in Drug Therapy
• Zusatzinfo: IX, 290 p.
• Verlagsort: Basel
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Pharmazie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• Schlagworte: biopharmaceuticals • Cancer • Cancer Therapy • Certolizumab pegol • Interferon • necrosis • Nucleotide • Pegfilgrastim • PEG Preparation • PEGylation technique • Pharmaceutical • Preparation • Protein • Protein conjugation • proteins • Research • Toxicity
• ISBN-10: 3-7643-8679-7 / 3764386797
• ISBN-13: 978-3-7643-8679-5 / 9783764386795