International Review of Neurobiology (eBook)

Ronald J. Bradley, Robert Adron Harris, Peter Jenner (Herausgeber)

eBook Download: PDF

1996 | 1. Auflage
380 Seiten
Elsevier Science (Verlag)
978-0-08-085773-2 (ISBN)

Infos

Since 1959, International Review of Neurobiology has been a well known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes.

Key Features
* Modulation of inhibitory and excitatory neurotransmitter receptors by protein phosphorylation
* The use-dependent regulation of GABAA receptors
* Mechanisms of synaptic transmission in the neostriatum
* Regulation of neurotransmitters function by the neuronal cytoskeleton
* The anatomy and physiology of opioids in the hippocampus
* The molecular biology and pharmacology of the cannabinoid receptor
* The use of invertebrate and mammalian model systems in the study of the anesthetic drug action
* Ethanol effects on ion channels and locomotion

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Since 1959, International Review of Neurobiology has been a well known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes. - Modulation of inhibitory and excitatory neurotransmitter receptors by protein phosphorylation- The use-dependent regulation of GABAA receptors- Mechanisms of synaptic transmission in the neostriatum- Regulation of neurotransmitters function by the neuronal cytoskeleton- The anatomy and physiology of opioids in the hippocampus- The molecular biology and pharmacology of the cannabinoid receptor- The use of invertebrate and mammalian model systems in the study of the anesthetic drug action- Ethanol effects on ion channels and locomotion

Inhalt

Front Cover 1
International Review of Neurobiology, Volume 39 4
Copyright Page 5
Contents 6
Preface 10
Chapter 1. Modulation of Amino Acid-Gated Ion Channels by Protein Phosphorylation 12
I. Introduction 13
II. Modulation of Inhibitory Neurotransmitter Receptors by Protein Phosphorylation 15
III. Phosphorylation of Excitatory Amino Acid Neurotransmitter Receptors 30
References 53
Chapter 2. Use-Dependent Regulation of GABAA Receptors 64
I. Introduction 65
II. Downregulation Produced by GABA and GABA-Mimetic Drugs 67
III. Downregulation Evoked by Benzodiazepines 75
IV. Downregulation Produced by Other GABAA Receptor Ligands 78
V. Ligand-Induced Upregulation of GABAA Receptors 79
VI. Conclusions 80
References 81
Chapter 3. Synaptic Transmission and Modulation in the Neostriatum 88
I. Introduction 89
II. The Anatomy of the Neostriatum and Basal Ganglia 91
III. Neurotransmitters in the Neostriatum and Basal Ganglia 93
IV. Membrane Properties of Principal Striatal Output Neurons and the Importance of Synaptic Drive in the Striatum 97
V. Corticostriatal Synaptic Transmission 97
VI. Dopaminergic Nigrostriatal Synaptic Transmission 100
VII. Presynaptic Regulation at Corticostriatal Synapses 102
VIII. Synaptic Plasticity at Striatal Synapses 106
IX. Summary 114
References 114
Chapter 4. The Cytoskeleton and Neurotransmitter Receptors 124
I. Introduction 125
II. The Cytoskeleton 126
III. The Diversity and Function of Microtubules 131
IV. Cytoskeleton-Affecting Agents 134
V. The Cytoskeleton and GABAA Receptors 137
VI. The Cytoskeleton and Other Neuronal Channels 142
VII. Neuropathology and the Cytoskeleton 145
VIII. Conclusions 147
References 148
Chapter 5. Endogenous Opioid Regulation of Hippocampal Function 156
I. Introduction 157
II. Opioids are Peptide Neurotransmitters 157
III. Anatomical Distributions 160
IV. Characterization of Cloned Receptors 165
V. Opioid Receptor-Mediated Effects in the Hippocampus 167
VI. Mechanisms of Neurotransmitter Release Inhibition by Opioid Receptors 170
VII. Opioid Modulation of Long-Term Potentiation 176
VIII. Hippocampal Opioids and Spatial Learning 184
IX. Hippocampal Opioids and Epilepsy 185
X. Summary and Conclusions 193
References 193
Chapter 6. Molecular Neurobiology of the Cannabinoid Receptor 208
I. Introduction 209
II. Pharmacology 210
III. Characterization of Brain and Peripheral Connabinoid Receptor Subtypes 216
IV. Future Directions 226
References 227
Chapter 7. Genetic Models in the Study of Anesthetic Drug Action 234
I. Introduction 235
II. lnvertebrate Model Systems 235
III. Mammalian Model Systems 238
IV. Summary 249
References 249
Chapter 8. Neurochemical Bases of Locomotion and Ethanol Stimulant Effects 254
I. Introduction 255
II. Psychomotor Stimulant Effects of Ethanol 256
III. Neurochemical Substances of Locomotion and Ethanol-Stimulated Activity 257
IV. Conclusions 284
References 285
Chapter 9. Effects of Ethanol on Ion Channels 294
I. Introduction 295
II. Glutamate Receptor Ion Channels 297
III. GABAA Receptor Ion Channels 317
IV. Glycine Receptor Ion Channels 327
V. Nicotinic Receptor Ion Channels 332
VI. 5-Hydroxytryptamine Receptor Ion Channels 342
VII. Purinergic P2X Receptor Ion Channels 343
VIII. Voltage-Gated Ca2+ Channels 344
IX. Voltage-Gated K+ Channels 348
X. Conclusions 351
References 353
Index 380

Produkt-Details

• Erscheint lt. Verlag: 2.12.1996
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• ISBN-10: 0-08-085773-6 / 0080857736
• ISBN-13: 978-0-08-085773-2 / 9780080857732