Biomarkers of Kidney Disease (eBook)

Charles L. Edelstein (Herausgeber)

eBook Download: EPUB

2010 | 1. Auflage
454 Seiten
Elsevier Science (Verlag)
978-0-12-375673-2 (ISBN)

Infos

A biomarker is a molecule that is measured as a marker of normal biological processes, disease processes or the response to a diagnostic or therapeutic intervention. Kidney diseases like acute kidney injury, chronic kidney disease, diabetic nephropathy, glomerular disease, renal cancer and preeclampsia still have a high morbidity. Measurement of biomarkers in the blood or urine that detect patients at risk of kidney diseases or that detect kidney diseases in the earliest stage may ultimately result in preventative or earlier or more effective treatments for kidney diseases.

Biomarkers of Kidney Disease reviews the basic and clinical research on biomarkers of the common kidney diseases including acute kidney injury, chronic kidney disease, renal cancer, diabetic nephropathy, glomerular disease and preeclampsia. The characteristics of an ideal biomarker of kidney diseases and statistical analysis of biomarker studies is detailed. The latest techniques for biomarker detection like metabolomics and proteomics is covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation and preeclampsia.

* Presents a comprehensive, translational source for all aspects of renal biomarkers in one reference work * Experts in renal disease biomarkers (from all areas of academic and medical research) take readers from the bench research (cellular and molecular mechanism) to new therapeutic approaches

Inhalt

Front Cover 1
Biomarkers in Kidney Disease 4
Copyright 5
Dedication 6
Contents 8
Contributors 12
Foreword 14
Preface 16
Chapter 1 Characteristics of an Ideal Biomarker of Kidney Diseases 18
1 The Discovery of Biomarkers 18
2 Characteristics of an Ideal Biomarker 21
3 Biomarkers in Acute Kidney Injury 23
4 Biomarkers in Chronic Kidney Disease 28
5 The Example of NGAL as a Biomarker of Acute Kidney Injury 31
References 37
Chapter 2 Statistical Considerations in Analysis and Interpretation of Biomarker Studies 42
1 Introduction 42
2 Planning a Study 44
3 Statistical Methods to Quantify Classification Performance 45
4 Sample Size Calculations 50
5 Emerging Methods 50
6 Summary 53
References 53
Chapter 3 The Role of Metabolomics in the Study of Kidney Diseases and in the Development of Diagnostic Tools 56
1 Introduction 57
2 Metabolic Mapping of the Kidney 63
3 Non-Targeted and Targeted Metabolomics 65
4 The Sample 71
5 Analytical Technologies 73
6 Metabolic Molecular Marker Discovery and Development 82
7 Metabolomics in Renal Research and as Kidney Function, Disease and Injury Marker 85
8 Metabolomics as Clinical Diagnostic Tool in Nephrology 102
References 109
Chapter 4 The Role of Proteomics in the Study of Kidney Diseases andnbspin the Development of Diagnostic Tools 118
1 Introduction 119
2 Non-targeted and Targeted Proteomics 123
3 Proteins and the Kidney 127
4 The Proteomics Sample 131
5 Analytical Technologies 133
6 Proteomics in Renal Research and as a Marker for Kidney Function, Disease and Injury 152
7 Proteomics as Clinical Diagnostic Tool innbspNephrology 175
References 180
Chapter 5 Biomarkers in Acute Kidney Injury 194
1 Serum Creatinine in Acute Kidney Injury 196
2 Interleukin-18 198
3 Neutrophil Gelatinase-associated Lipocalin 203
4 Kidney Injury Molecule-1 209
5 Tubular Enzymes 212
6 Cystatin C 214
7 Other Biomarkers of Acute Kidney Injury 218
8 Combinations of AKI Biomarkers 226
9 Summary 228
10 Biomarkers of Extra-renal Complications of Acute Kidney Injury 229
References 239
Chapter 6 Biomarkers in Kidney Transplantation 250
1 Biomarkers: An Overview 251
2 Biomarkers of Acute Kidney Injury Post-transplantation (Table 6.1) 251
3 Biomarkers of Acute Rejection (Table 6.2) 262
4 Biomarkers of Chronic Allograft Nephropathy (Table 6.4) 290
5 Biomarkers of Polyoma Virus Infection 296
6 Summary 300
References 301
Chapter 7 Cystatin C as a Biomarker in Kidney Disease 308
1 Structure and Function of Cystatin C 308
2 Cystatin C Gene Structure and Cystatin C Production 309
3 Catabolism of Cystatin C 310
4 Cystatin C as a Marker for Glomerular Filtration Rate 311
5 Creatinine- and Cystatin C-based GFR-prediction Equations 315
6 The Lund Model: GFR-estimation with an Internal Quality Control 318
7 Abnormal Glomerular Filtration Quality: A New Marker for Kidney Disease. Use of Cystatin C to Identify It 319
8 Cystatin C and Aging Success 321
References 322
Chapter 8 Biomarkers of Renal Cancer 330
1 Renal Cancer 330
2 Cancer Biomarkers - General Concepts 336
3 Renal Cancer Biomarkers 337
4 Conclusions 361
References 361
Chapter 9 Urinary Proteomics and Candidate Biomarker Discovery for Diabetic Nephropathy 368
1 Introduction 369
2 Urinary Proteins as Candidate Biomarkers of Diabetic Nephropathy 371
3 Urinary Peptides as Candidate Biomarkers of Type 2 Diabetic Nephropathy and Chronic Kidney Disease 374
4 Urinary Peptides as Candidate Biomarkers of Early Progressive Renal Function Declinenbspin Type 1 Diabetic Nephropathy 376
5 A Targeted Proteomic Analysis for Candidate Biomarkers of Early Renal Function Declinenbspin Type 1 Diabetic Nephropathy 380
6 Future Developments and Applications of Proteomics for Biomarker Discovery 381
References 382
Chapter 10 Biomarkers in Glomerular Disease 384
1 Biomarkers in Glomerular Diseases 385
2 Biomarkers in Lupus Nephritis 385
3 Membranous Nephropathy 389
4 Focal Segmental Glomerulosclerosis 391
5 Minimal Change Disease 392
6 IgA Nephropathy 393
7 ANCA-associated Vasculitis 395
8 Discovery of New Biomarkers using Proteomics 396
References 398
Chapter 11 Biomarkers in Preeclampsia 402
1 Definition and Prevalence of the Disease 403
2 Pathophysiology and Mechanisms 404
3 Clinical Manifestations 406
4 Diagnosis 410
5 Biomarkers 412
6 Novel Biomarkers and Future Perspectives 431
7 Conclusion 434
References 435
Index 444

Produkt-Details

• Erscheint lt. Verlag: 27.10.2010
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Nephrologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Urologie
• Themenwelt: Medizin / Pharmazie ► Pflege
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• ISBN-10: 0-12-375673-1 / 0123756731
• ISBN-13: 978-0-12-375673-2 / 9780123756732