Cytoskeleton of the Nervous System (eBook)
XV, 774 Seiten
Springer New York (Verlag)
978-1-4419-6787-9 (ISBN)
Ralph A. Nixon is the Director of Silberstein Institute and Center of Excellence on Brain Aging; a Professor of Psychiatry and Cell Biology at NYU Langone Medical Center; the Director of Research and The Center for Dementia Research at Nathan S. Kline Institute for Psychiatric Research. Aidong (David) Yuan is the Research Project Manager at the Center for Dementia Research, Nathan S. Kline Institute; a Research Assistant Professor of Psychiatry at New York University Langone Medical Center and New York University School of Medicine.
This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.
Ralph A. Nixon is the Director of Silberstein Institute and Center of Excellence on Brain Aging; a Professor of Psychiatry and Cell Biology at NYU Langone Medical Center; the Director of Research and The Center for Dementia Research at Nathan S. Kline Institute for Psychiatric Research. Aidong (David) Yuan is the Research Project Manager at the Center for Dementia Research, Nathan S. Kline Institute; a Research Assistant Professor of Psychiatry at New York University Langone Medical Center and New York University School of Medicine.
Chapter 1: Central Axonal Development and Pathology in Early Life
Robin L. Haynes, Hannah C. Kinney
Chapter 2: Microtubules in the nervous system
Nobuyuki Fukushima
Chapter 3: Tau phosphorylation
Jesús Avila, Félix Hernández
Chapter 4: Tau Pathology
Nicolas Sergeant, Luc Buée
Chapter 5: Tauopathy and brain aging
Akihiko Takashima
Chapter 6: Microtubule-associated protein 4
Kiyotaka Tokuraku, Kazuyuki Matsushima, Hiroyuki Nakagawa, Susumu Kotani
Chapter 7: Structure of Neural Intermediate Filaments
David A.D. Parry
Chapter 8: Alpha-internexin: the Fourth Subunit of Neurofilaments in the Mature CNS
Aidong Yuan, Ralph A. Nixon
Chapter 9: Peripherin Pathology
Jesse R. McLean, Janice Robertson
Chapter 10: Neurofilament cross-bridge: a structure associated specifically with the neurofilament among the intermediate filament family
Takahiro Gotow
Chapter 11: Neurofilament Transport
Andrew J Grierson and Christopher C.J Miller
Chapter 12: Knockout models of neurofilament proteins
Rodolphe Perrot, Jean-Pierre Julien
Chapter 13: Neurofilaments and Radial Growth: Deconstruction of a hypothesis through the construction of gene targeted mice
Michael L. Garcia, Devin M. Barry
Chapter 14: Deregulation of Cytoskeletal Protein Phosphorylation and Neurodegeneration
Jyotshnabala Kanungo, Ya-li Zheng, Parvathi Rudrabhatla, Niranjana D. Amin, Bibhutibhushan Mishra, Harish C. Pant
Chapter 15: Neurofilaments in Aged Animals
Shin-ichi Hisanaga, Takahiro Sasaki, Atsuko Uchida
Chapter 16: Neurofilament changes in Multiple Sclerosis
Elizabeth Gray, Alastair Wilkins
Chapter 17: Intermediate filament interactions in neurons
Kevin G. Young, Rashmi Kothary
Chapter 18: Tropomyosins in Neuronal Morphogenesis and Development
Nikki Margarita Curthoys, Peter William Gunning, Thomas Fath
Chapter 19: The Driving Machinery for Growth Cone Navigation
Takuro Tojima, Hiroyuki Kamiguchi
Chapter 20: Glial Fibrillary Acidic Protein: The intermediate filament protein of astrocytes
Douglas L. Eng, Lawrence F. Eng
Chapter 21: Axonal Transport Mechanisms in Cytoskeleton Formation and Regulation
Aidong Yuan, Ralph A. Nixon
Chapter 22: Axonal transport and motor neuron disease
Anna-Lena Ström, Lawrence J. Hayward, Edward J. Kasarskis, Haining Zhu
Chapter 23: In vivo imaging of axonal transport in aging and Alzheimer's disease
Donna J. Cross, Satoshi Minoshima
Chapter 24: Regulation of Cytoskeletal Composition in Neurons: Transcriptional and Post-transcriptional Control in Development, Regeneration, and Disease
Ben G. Szaroa, Michael J. Strong
Chapter 25: Crosstalks between myelinating cells and the axonal cytoskeleton
Rodolphe Perrot, Joël Eyer
Chapter 26: Topographic regulation of neuronal intermediate filament proteins by phosphorylation: In health and disease
Parvathi Rudrabhatla, Harish C Pant
Chapter 27: Cytoskeleton, axonal transport, and the mechanisms of axonal neuropathy
Hsinlin T Cheng, Brian Callaghan, Jacqueline R Dauch and Eva L Feldman
Chapter 28: Effects of Insulin on Tau and Neurofilament
R. Schechter, K.E. Miller
Chapter 29: Ethanol effects on the cytoskeleton of nerve tissue cells
Sergio G. Evrard, Alicia Brusco
| Erscheint lt. Verlag | 4.2.2011 |
|---|---|
| Reihe/Serie | Advances in Neurobiology | Advances in Neurobiology |
| Zusatzinfo | XVI, 774 p. 117 illus., 56 illus. in color. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| ISBN-10 | 1-4419-6787-7 / 1441967877 |
| ISBN-13 | 978-1-4419-6787-9 / 9781441967879 |
| Haben Sie eine Frage zum Produkt? |
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