Current Topics in Innate Immunity (eBook)

John D. Lambris (Herausgeber)

eBook Download: PDF

2007 | 2007
XXV, 432 Seiten
Springer New York (Verlag)
978-0-387-71767-8 (ISBN)

Infos

In the post genomic era, understanding of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. This volume covers natural killer cells, mast cells, phagocytes, toll-like receptors, complement, host defense in plants and invertebrates, evasion strategies of microorganisms, pathophysiology, protein structures, design of therapeutics, and experimental approaches.

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Innate Immunity has long been regarded as the non-specific arm of immune response, acting immediately and in a generic way, to defend the host from infections. In the post genomic era, our knowledge of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. Several studies indicate that molecules involved in innate immunity exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system.The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led scientists to revisit established biological systems from a global and integrative perspective. Innate Immunity research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. In this respect, scientists from around the world convened at the 4th International Conference on Innate Immunity (June 4 - 9, 2006), in Corfu, Greece to discuss recent advances in this fast evolving field.This volume represents a collection of topics on natural killer cells, mast cells, phagocytes, toll like receptors, complement, host defense in plants and invertebrates, evasion strategies of microorganisms, pathophysiology, protein structures, design of therapeutics, and experimental approaches discussed during the conference.

Inhalt

Preface 6
Toll-like Receptors, Natural Killer Cells and Innate Immunity 26
In the Thick of the Fray: NK Cells in Inflamed Tissues 37
Structural Insight into Natural Killer T Cell Receptor Recognition of CD1d 45
The Journey of Toll-like Receptors in the Cell 60
Differential Regulation of Key Signaling Molecules in Innate Immunity and Human Diseases 74
Systems Biology of Macrophages 87
The Alternative Pathway of Complement: a Pattern Recognition System 105
Role of MBL-associated Serine Protease (MASP) On Activation of the Lectin Complement Pathway 118
C3a Receptors Signaling in Mast Cells 151
Antimicrobial C3a –Biology, Biophysics, and Evolution 166
C5L2 – an Anti-inflammatory Molecule or a Receptor for Acylation Stimulating Protein ( C3a- desArg)? 184
The Exosporium of B.cereus Contains a Binding Site for gC1qR/ p33: Implication in Spore Attachment and/ or Entry* 206
Immunity in Borreliosis with Special Emphasis on the Role of Complement 223
Murine CR1/2 Targeted Antigenized Single-Chain Antibody Fragments Induce Transient Low Affinity Antibodies and Negatively Influence an Ongoing Immune Response 239
The Third Complement Component as Modulator of Platelet Production 251
In Vivo Biological Responses in the Presence or Absence of C3 265
Complement Activation of Drusen in Primate Model ( Macaca fascicularis) for Age- Related Macular Degeneration 276
Exploring the Complement Interaction Network Using Surface Plasmon Resonance 285
Glycosylation as a Target for Recognition of Influenza Viruses by the Innate Immune System 304
Immune Effects of Autoantigen-Associated RNA 318
Induction and Evasion of the Type I Interferon Response by Cytomegaloviruses 334
Pore Formers of the Immune System 350
Pathogen-Specific Innate Immune Response 367
Flagellin Signalling in Plant Immunity 383
Ancient Origin of the Complement System: Emerging Invertebrate Models 397
Biological Roles of Lectins in Innate Immunity: Molecular and Structural Basis for Diversity in Self/ Non- Self Recognition 414
Hydrogen/Deuterium Exchange Mass Spectrometry: Potential for Investigating Innate Immunity Proteins 432
Index 443

Produkt-Details

• Erscheint lt. Verlag: 7.9.2007
• Reihe/Serie: Advances in Experimental Medicine and Biology
• Reihe/Serie: Advances in Experimental Medicine and Biology
• Zusatzinfo: XXV, 432 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• Schlagworte: Antigen • Antimicrobial • Infection • Infections • Infectious Diseases • Interferon • Microorganism • pathophysiology • Physiology • RNA • Virus
• ISBN-10: 0-387-71767-6 / 0387717676
• ISBN-13: 978-0-387-71767-8 / 9780387717678