Central Nervous System Diseases and Inflammation (eBook)

Conni Bergmann, Monica Carson, Thomas E. Lane, Tony Wyss-Coray (Herausgeber)

eBook Download: PDF

2007 | 2008
VIII, 318 Seiten
Springer US (Verlag)
978-0-387-73894-9 (ISBN)

Infos

Edited and authored by top names in the field, this book provides a succinct reference on inflammatory central nervous system disease. It focuses on current areas of investigation in the fields of neuroimmunology, virology, pharmacology, and disease. Sections focus on specific categories of diseases, examining the pharmacological, virological, and immunological effects of and on the disease. This book's unique organization provides a concise overview of inflammatory CNS disease.

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Up until approximately 20 years ago, the idea that the central nervous system (CNS) and components of the immune system were dynamically interactive was considered impossible (or at least highly unlikely) as the CNS was judged an immunosuppressive environment based upon experimental evidence highlighting the survival of tissue grafts within the brain. Additional evidence supporting this viewpoint included (i) the presence of the blood-brain barrier (BBB) which p- vides a physical and physiological obstruction that is difficult for cells and mac- molecules to cross, (ii) the relative absence of MHC class I and II expression on CNS cells like astrocytes and neurons, and (iii) lack of abundant antigen presenting cells (APC) which are required for the generation of an adaptive immune response. However, in spite of these obstacles, it is now well-accepted that the CNS is r- tinely subject to immune surveillance under both normal as well as diseased con- tions. Indeed, activated cells of the immune system such as T and B lymphocytes and monocyte/macrophages readily infiltrate and accumulate within the CNS f- lowing microbial infection, injury, or upon development of autoimmune responses directed toward resident antigens of the CNS.

Inhalt

Preface 5
Contents 7
Microglia: A CNS-Specific Tissue Macrophage 9
Mechanisms of Microglial Activation by Amyloid Precursor Protein and its Proteolytic Fragments 21
Pericytes 41
Imaging Microglia in the Central Nervous System: Past, Present and Future 52
Cytokines in CNS Inflammation and Disease 65
Arachidonic Acid Metabolites: Function in Neurotoxicity and Inflammation in the Central Nervous System 113
Pattern Recognition Receptors in CNS Disease 136
Central Nervous System Diseases and Inflammation 158
Chemokines and Autoimmune Demyelination 180
Chemokine Actions in the CNS: Insights from Transgenic Mice 207
Chemokines and Spinal Cord Injury 224
The Usual Suspects: Chemokines and Microbial Infection of the Central Nervous System 237
CNS Dendritic Cells in Inflammation and Disease 264
MHC Class I Expression and CD8 T Cell Function: Towards the Cell Biology of T- APC Interactions in the Infected Brain 277
Index 307
Color Plates 314

Produkt-Details

• Erscheint lt. Verlag: 24.12.2007
• Zusatzinfo: VIII, 318 p. 10 illus., 9 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Antigen • biochemistry • Chemokine • Microbiology • nervous system • Neurology • neurotoxicity • Protein • Virology
• ISBN-10: 0-387-73894-0 / 0387738940
• ISBN-13: 978-0-387-73894-9 / 9780387738949