The Proteasome in Neurodegeneration (eBook)

Leonidas Stefanis, J. N. Keller (Herausgeber)

eBook Download: PDF

2007 | 2006
XV, 306 Seiten
Springer US (Verlag)
978-0-387-28500-9 (ISBN)

Infos

In the last 50 years a wealth of information has allowed us to understand the contribution of various regulatory factors that alter mRNA and protein s- thesis to a variety of physiological and pathological conditions. However, such regulation is only one of many factors that contribute to the levels of a given p- tein. One major factor that has been relatively obscure until recently has been the contribution of protein degradation to the regulation of the steady state level of protein expression and protein function. This rapidly evolving field has made a significant mark on the scientific community, as highlighted by the Award of the Nobel Prize in Chemistry for 2004 to Aaron Ciechanover, Avram Hershko and Irwin Rose for their pioneering work on the ubiquitin-proteasome system (UPS) of protein degradation, which is the subject of this volume. In recent years e- dence has been accumulating that suggests a role for UPS function in both ph- iological and pathological settings. In particular, studies have implicated a central role for the UPS in cell cycle regulation, cancer and neurodegeneration. Two points are however worth bearing in mind: First, ubiquitin's function appears to extend far beyond the UPS and protein degradation; second, there are other important systems of intracellular protein degradation, most notably autophagic systems through the lysosomes, and these may also be involved in disease pat- physiology.

Inhalt

CONTRIBUTORS 5
PREFACE 8
CONTENTS 11
YEAST PROTEASOME STRUCTURE AND BIOGENESIS 14
UBIQUITIN-PROTEASOME SYSTEM IN THE CENTRAL NERVOUS SYSTEM 30
PROTEIN AGGREGATION AND THE UPS: A TWO-WAY STREET 51
THE IMPACT OF INCLUSION FORMATION ON CELL SURVIVAL 68
INCLUSION FORMATION AND DISOLUTION FOLLOWING PROTEASOMAL INHIBITION IN NEURONAL CELLS 79
THE PROTEASOME: SOURCE AND A TARGET OF OXIDATIVE STRESS? 95
INFLAMMATION AS A MEDIATOR OF OXIDATIVE STRESS AND UPS DYSFUNCTION 114
ROLE OF THE UBIQUITIN PROTEASOME SYSTEM DURING NEURONAL CELL DEATH 141
PATHWAYS OF NEURONAL CELL DEATH INDUCED BY PROTEASOMAL INHIBITION 157
PHARMACOLOGICAL AND MOLECULAR MODELS OF PROTEASOMAL DYSFUNCTION 174
THE GAD MOUSE: A WINDOW INTO UPS- RELATED NEURODEGENERATION AND THE FUNCTION OF THE FUNCTION OF THE DEUBIQUITINATING ENZYME UCH– L1 191
PARKINSON’S DISEASE AND RELATED DISORDERS 205
UBIQUITINATION BY PARKIN – IMPLICATIONS IN PARKINSON’S DISEASE 219
THE UPS IN NEURODEGENERATIVE DISEASES AND AGING 231
FRAMESHIFT MUTANT UBIQUITIN IN ALZHEIMER’S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS 242
MOTOR NEURON DISEASE 252
THE PARADOXICAL ROLE OF PROTEASOMES IN PRION DISORDERS 270
AGING AND THE PROTEASOME 289
INDEX 303

Produkt-Details

• Erscheint lt. Verlag: 2.8.2007
• Zusatzinfo: XV, 306 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Schlagworte: Keller • nervous system • Neurodegeneration • Neuroscience • Parkinson • Proteasome • Stefanis
• ISBN-10: 0-387-28500-8 / 0387285008
• ISBN-13: 978-0-387-28500-9 / 9780387285009