Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks (eBook)

Peter Csermely, László Vígh (Herausgeber)

eBook Download: PDF

2007 | 2007
XVIII, 201 Seiten
Springer New York (Verlag)
978-0-387-39975-1 (ISBN)

Infos

This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.

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We are extremely happy to present the reader this book containing a summary of a well-known research field, the phenomenon of cellular stress defense from two new angles: networks and membranes. The volume starts with an introduction to the concept of molecular chaperones in their original sense: R. John Ellis, the founder of the chaperone concept describes chaperones as mediators of correct assembly and/or misassembly of other macromolecular complexes. This sets the tone of the book, where later chapters give detailed examples of the richness of chaperone ac- tion by hundreds of other proteins and membrane structures. The reader will learn the role of chaperone classes such as Hsp27 or Hsp90, the action of highly organized chaperone networks in various cellular compartments such as the ER or mitochondrial/ER networks as well as the molecular details of the signaling mechanisms leading to chaperone induction during stress. Various special stress defense mechanisms against oxidative stress or dryness will also be covered. Membranes comprise a surprising mixture of stability and dynamics in the cell. Their role in the regulation of the stress response has been accepted only slowly in the field. Two chapters summarize this important aspect of the stress response showing the importance of membrane hyperstructures, lipid species composition, protein/ membrane interactions and cold adaptation.

Inhalt

PREFACE 6
ABOUT THE EDITORS... 7
PARTICIPANTS 9
CONTENTS 13
Protein Misassembly: Macromolecular Crowding and Molecular Chaperones 19
The Cellular " Networking" of Mammalian Hsp27 and Its Functions in the Control of Protein Folding, Redox State and Apoptosis 32
Molecular Interaction Network of the Hsp90 Chaperone System 45
Organization of the Functions and Components of the Endoplasmic Reticulum 55
Molecular Crime and Cellular Punishment: Active Detoxification of Misfolded and Aggregated Proteins in the Cell by the Chaperone and Protease Networks 65
Chaperones as Parts of Cellular Networks 73
Chaperones as Parts of Organelle Networks 82
Heat Shock Factor 1 as a Coordinator of Stress and Developmental Pathways 96
Chaperone Regulation of the Heat Shock Protein Response 107
Mechanisms of Activation and Regulation of the Heat Shock- Sensitive Signaling Pathways 118
Membrane-Regulated Stress Response: A Theoretical and Practical Approach 132
Beyond the Lipid Hypothesis: Mechanisms Underlying Phenotypic Plasticity in Inducible Cold Tolerance 150
Trehalose As a "Chemical Chaperone'': Fact and Fantasy 161
Chaperones As Part of Immune Networks 177
The Stress of Misfolded Proteins: C. elegans Models for Neurodegenerative Disease and Aging 185
Hsp90 and Developmental Networks 208
Index 216

Produkt-Details

• Erscheint lt. Verlag: 9.8.2007
• Reihe/Serie: Advances in Experimental Medicine and Biology
• Reihe/Serie: Advances in Experimental Medicine and Biology
• Zusatzinfo: XVIII, 201 p. 55 illus., 1 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Technik
• Schlagworte: Activation • Chaperone • chaperones • Csermely • Lipid • Organelle • Regulation • response • Stress
• ISBN-10: 0-387-39975-5 / 0387399755
• ISBN-13: 978-0-387-39975-1 / 9780387399751