Kernicterus (eBook)
XIV, 286 Seiten
Springer New York (Verlag)
978-1-4419-6555-4 (ISBN)
Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 26th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine.Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others
Kernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment. In the absence of treatment kernicterus can produce devastating sequelae and death. The present volume will examine the biochemistry and physiology of bilirubin as well as its hepatic metabolism and renal excretion. Chapters will elaborate bodily disposition of bilirubin and its neuropathology. Both early treatments and current therapy will be discussed in detail. Phototherapy will be presented, and its efficacy and influence on incidence thoroughly examined.
Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 26th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine.Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others
Preface 5
Acknowledgements 8
Contents 9
Prologue: World Health Concerns 11
History of Bilirubin 20
Biochemistry and Physiology of Bilirubin 27
Premature Birth 40
Erythroblastosis Fetalis 49
The Gunn Rat Model 57
CriglerNajjar Syndrome 71
Neuropathology of Kernicterus 86
Bilirubin and Energy Metabolism 99
Jaundice and Other Biochemical Changes 113
Breast Milk Jaundice 119
Jaundice in Malaria 125
Jaundice in Congenital Hypertrophic Pyloric Stenosis 136
Phototherapy for Hyperbilirubinemia 143
Non-phototherapy Treatment 154
Hyperbilirubinemia Revisited 162
Auditory Brainstem Response 175
Progressive Familial Intrahepatic Cholestasis 188
Kernicterus in Older Children and Adults 201
Cerebral Palsy and Counseling 207
Neurological Sequelae from Jaundice 216
Neurobehavioral Teratology 224
Gene Therapy for Hyperbilirubinemia 232
Epilogue: Comments and Future Directions 242
Appendix Sources 248
References 250
Index 269
| Erscheint lt. Verlag | 2.9.2010 |
|---|---|
| Reihe/Serie | Contemporary Clinical Neuroscience | Contemporary Clinical Neuroscience |
| Zusatzinfo | XIV, 286 p. |
| Verlagsort | Totowa |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Gesundheitsfachberufe ► Diätassistenz / Ernährungsberatung |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie | |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| ISBN-10 | 1-4419-6555-6 / 1441965556 |
| ISBN-13 | 978-1-4419-6555-4 / 9781441965554 |
| Haben Sie eine Frage zum Produkt? |
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