Pharmaco-Complexity (eBook)
VIII, 71 Seiten
Springer US (Verlag)
978-1-4419-7856-1 (ISBN)
Dr. Anthony Hickey is Professor of Molecular Pharmaceutics and Biomedical Engineering at the University of North Carolina at Chapel Hill. He is a fellow of the Institute of Biology, American Association of Pharmaceutical Scientists and the American Association for the Advancement of Science. He has published several edited and authored volumes in the fields of pharmaceutical aerosols, process engineering and particulate science.
Dr. Hugh Smyth is Assistant Professor of Pharmaceutics at the University of Texas, Austin. He is a recipient of the Young Investigator in Pharmaceutics and Pharmaceutical Technology Award of the American Association of Pharmaceutical Scientists and has edited a volume on pulmonary drug delivery. Drs. Hickey and Smyth share a research interest in the delivery of drugs to the lungs for the treatment and prevention of a number of diseases.
The historical approach to the interpretation of physical, chemical and biological phenomena has been to consider relationships with causative factors that can be reduced to linearity allowing simple and direct interpretation. However, it is increasingly evident that there is often more information in the data than linear interpretations allow. The current capacity for computers to assist in identifying non-linear relationships allows greater interpretation of data which illuminates the phenomena allowing the information to be translated into knowledge that can be used wisely to promote various desirable pharmaceutical outcomes. This short volume is intended to stimulate the reader to contemplate research and development areas in which the data might be more accurately interpreted to allow greater understanding and ultimately control of the pharmaceutically complex phenomena.
Dr. Anthony Hickey is Professor of Molecular Pharmaceutics and Biomedical Engineering at the University of North Carolina at Chapel Hill. He is a fellow of the Institute of Biology, American Association of Pharmaceutical Scientists and the American Association for the Advancement of Science. He has published several edited and authored volumes in the fields of pharmaceutical aerosols, process engineering and particulate science. Dr. Hugh Smyth is Assistant Professor of Pharmaceutics at the University of Texas, Austin. He is a recipient of the Young Investigator in Pharmaceutics and Pharmaceutical Technology Award of the American Association of Pharmaceutical Scientists and has edited a volume on pulmonary drug delivery. Drs. Hickey and Smyth share a research interest in the delivery of drugs to the lungs for the treatment and prevention of a number of diseases.
Pharmaco-Complexity 3
Preface 5
Contents 7
Chapter 1: The Nature of Complexity and Relevance to Pharmaceutical Sciences 9
References 12
Chapter 2: Phenomena in Physical and Surface Chemistry 13
Chemical Reactions 13
Surface and Interfacial Chemistry 14
Aggregation 15
Adsorption from Solution 18
Solid Surface Interaction 21
Summary 23
References 23
Chapter 3: Solid State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation 27
Statics 28
Solubility, Dissolution, and Release 28
Fractal Dimensions and Surface Phenomena 29
Monte Carlo Methods in Modeling Drug Release 30
Surfaces and Particles 32
Complexity of Crystallization 32
Complexity of Particle Shape 34
Dynamics 35
Powder Flow and Mixing 35
Summary 39
References 39
Chapter 4: Considerations in Monitoring and Controlling Pharmaceutical Manufacturing 45
Statistics and Experimental Design 45
Sources of Error 45
Randomized and Latin Square Designs 46
Factorial Design 46
Fractional Factorial Design 47
Central Composite Design 47
Response Surface Maps 47
Process Design and Control 48
Quality by Design 48
Design Space 49
Process Analytical Technology 50
Risk Assessment and Management 51
Summary 52
References 52
Chapter 5: Pharmacokinetics and Pharmacodynamics 54
Pharmacokinetics/Toxicokinetics 54
Compartmental Modeling 55
Fractal Kinetics 56
Physiologically Relevant Modeling 57
Efficacy/Safety 57
Summary 60
References 60
Chapter 6: Impact of Complexity on Population Biology 62
Nature of Disease 62
Potential for Disease Intervention 63
Epidemiological Studies and Adverse Events 64
Summary 65
References 65
Chapter 7: Conclusion 67
References 72
Index 73
About the Authors 76
| Erscheint lt. Verlag | 15.12.2010 |
|---|---|
| Reihe/Serie | Outlines in Pharmaceutical Sciences | Outlines in Pharmaceutical Sciences |
| Zusatzinfo | VIII, 71 p. 9 illus., 2 illus. in color. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Gesundheitsfachberufe |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Medizin / Pharmazie ► Pharmazie | |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Technik ► Umwelttechnik / Biotechnologie | |
| Schlagworte | Complexity • Development • Drug • Hickey • Pharmaco • Phenomena • Product • Smyth |
| ISBN-10 | 1-4419-7856-9 / 1441978569 |
| ISBN-13 | 978-1-4419-7856-1 / 9781441978561 |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
| Haben Sie eine Frage zum Produkt? |
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