Sarcopenia – Age-Related Muscle Wasting and Weakness (eBook)

Mechanisms and Treatments

Gordon S. Lynch (Herausgeber)

eBook Download: PDF

2010 | 2011
XIII, 479 Seiten
Springer Netherland (Verlag)
978-90-481-9713-2 (ISBN)

Infos

Some of the most serious consequences of aging are its effects on skeletal muscle. 'Sarcopenia', the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional independence. Not surprisingly, sarcopenia is a significant public health problem throughout the developed world. There is an urgent need to better understand the neuromuscular mechanisms underlying age-related muscle wasting and to develop therapeutic strategies that can attenuate, prevent, or ultimately reverse sarcopenia. Significant research and development in academic and research institutions and in pharmaceutical companies is being directed to sarcopenia and to related health issues in order to develop and evaluate novel therapeutics. This book provides the latest information on sarcopenia from leading international researchers studying the cellular and molecular mechanisms underlying age-related changes in skeletal muscle and identifies strategies to combat sarcopenia and related muscle wasting conditions and neuromuscular disorders. The book provides a vital resource for researchers and practitioners alike, with information relevant to gerontologists, geriatricians, sports medicine physicians, physiologists, neuroscientists, cell biologists, endocrinologists, physical therapists, allied health and musculoskeletal practitioners, strength and conditioning specialists, athletic trainers, and students of the medical and biomedical sciences.

Inhalt

Contents 8
Contributors 10
Overview of Sarcopenia 16
Muscle Wasting in Cancer and Ageing: Cachexia Versus Sarcopenia 23
Age-Related Remodeling of Neuromuscular Junctions 50
Aging-Related Changes Motor Unit Structure and Function 68
Age-Related Decline in Actomyosin Structure and Function 88
Excitation-Contraction Coupling Regulation in Aging Skeletal Muscle 125
Alterations in Mitochondria and Their Impact in Aging Skeletal Muscle 147
Skeletal Muscle Collagen: Age, Injury and Disease 171
Nuclear Apoptosis and Sarcopenia 185
Age-Related Changes in the Molecular Regulation of Skeletal Muscle Mass 219
Genetic Variation and Skeletal Muscle Traits: Implications for Sarcopenia 234
Proteomic and Biochemical Profiling of Aged Skeletal Muscle 269
Exercise and Nutritional Interventions to Combat Age- Related Muscle Loss 298
Reactive Oxygen Species Generation and Skeletal Muscle Wasting – Implications for Sarcopenia 325
Exercise as a Countermeasure for Sarcopenia 340
Role of Contraction-Induced Injury in Age- Related Muscle Wasting and Weakness 379
Role of IGF-1 in Age-Related Loss of Skeletal Muscle Mass and Function 398
Role of Myostatin in Skeletal Muscle Growth and Development: Implications for Sarcopenia 424
Role of b- Adrenergic Signalling in Skeletal Muscle Wasting: Implications for Sarcopenia 453
Index 476

Produkt-Details

• Erscheint lt. Verlag: 30.11.2010
• Zusatzinfo: XIII, 479 p.
• Verlagsort: Dordrecht
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Sportmedizin
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Technik
• Schlagworte: aging • Neuromuscular biology • Skeletal muscle • sports medicine • therapy
• ISBN-10: 90-481-9713-9 / 9048197139
• ISBN-13: 978-90-481-9713-2 / 9789048197132