5-HT2C Receptors in the Pathophysiology of CNS Disease (eBook)

Giuseppe di Giovanni, Ennio Esposito, Vincenzo Di Matteo (Herausgeber)

eBook Download: PDF

2010 | 2011
XII, 560 Seiten
Humana Press (Verlag)
978-1-60761-941-3 (ISBN)

Infos

Part of Springer's 'The Receptors,' series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors' therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson's disease, Prader-Willi Syndrome, Alzheimer's disease and epilepsy.

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Part of Springer's "e;The Receptors,"e; series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors' therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson's disease, Prader-Willi Syndrome, Alzheimer's disease and epilepsy.

Inhalt

Chapter 1The making of the 5-HT2C receptor
Jose M. Palacios, Angel Pazos and Daniel Hoyer

Chapter 2Serotonin 5-HT2C receptors: chemical neuronatomy in the mammalian brain
Guadalupe Mengod

Chapter 3The medicinal chemistry of 5-HT2C receptor ligands
Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Francesco Berardi, Roberto Perrone

Chapter 4Insights into 5-HT2C receptor function gained from transgenic mouse models
Stephen J. Bonasera

Chapter 5Serotonin 5-HT2C receptor signal transduction
Maria N. Garnovskaya and John R. Raymond

Chapter 6Homology modeling of 5-HT2C receptors
Nicolas Renault, Amaury Farce, Philippe Chavatte

Chapter 75-HT2C receptor dimerization
Katharine Herrick-Davis and Dinah T. Farrington

Chapter 8RNA editing of 5-HT2C receptor and neuropsychiatric diseases
Kazuya Iwamoto, Miki Bundo and Tadafumi Kato

Chapter 9Serotonergic control of adult neurogenesis: focus on 5-HT2C receptors
Annie Daszuta

Chapter 10The constitutive activity of 5-HT2C receptors as an additional modality of interaction of the serotonergic system
Sylvia Navailles, Philippe De Deurwaerdère

Chapter 11The 5-HT2C receptor subtype controls central dopaminergic systems: evidence from electrophysiological and neurochemical studies
Giuseppe Di Giovanni, Ennio Esposito and Vincenzo Di Matteo

Chapter 12The role of serotonin-2C receptors in the pathophysiology of depression
Eliyahu Dremencov, Joost HA Folgering, Sandra Hogg, Laurence Tecott and Thomas I.F.H. Cremers

Chapter 135-HT2C receptors and suicidal behaviour
Fabio Panariello, Naima Javaid and Vincenzo De Luca

Chapter 14The 5-HT2C receptor as a target for schizophrenia
Herbert Y Meltzer, Liwen Sun and Hitoshi Hashimoto

Chapter 15Serotonin and reward-related behaviour: focus on 5-HT2C receptors
Paul J. Fletcher and Guy A. Higgins

Chapter 16Tat-3L4F: a novel peptide for treating drug addiction by disrupting interaction between PTEN and 5-HT2C receptor
Amy Hu, Lintao Jia, Jean-Christian Maillet, Xia Zhang

Chapter 17The role of serotonin in eating behaviour: focus on 5-HT2C receptors
Jason C.G. Halford

Chapter 18Physiological and pathophysiological aspects of 5-HT2C receptors in basal ganglia
Philippe De Deurwaerdère, Laurence Mignon and Marie-Françoise Chesselet

Chapter 19Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment
Richard M. Kostrzewa

Chapter 20The role of 5-HT2A/2C receptors in sleep and waking
Jaime M. Monti and Héctor Jantos

Chapter 21Role of alternative splicing of the 5-HT2C in the Prader-Willi syndrome
Shivendra Kishore and Stefan Stamm

Chapter 22The role of 5-HT2C receptor in epilepsy
Rita Jakus and Gyorgy Bagdy

Chapter 23The role of serotonin on attentional processes and executive functioning: focus on 5-HT2C receptors
Eleftheria Tsaltas and Vasileios Boulougouris

Chapter 245-HT2C receptors in learning
López-Vázquez Miguel Ángel, Gutiérrez-Guzmán Blanca Érika, Cervantes Miguel and Olvera-Cortés María Esther

Chapter 25The role of 5-HT2C polymorphisms in behavioural and psychological symptoms of alzheimer's disease
Antonia Pritchard

Chapter 26Ocular hypotension: involvement of serotonergic 5-HT2C receptors
Najam A. Sharif

Produkt-Details

• Erscheint lt. Verlag: 30.11.2010
• Reihe/Serie: The Receptors
• Reihe/Serie: The Receptors
• Zusatzinfo: XII, 560 p.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• ISBN-10: 1-60761-941-5 / 1607619415
• ISBN-13: 978-1-60761-941-3 / 9781607619413