Biopacemaking (eBook)

J.A.E Spaan, Ruben Coronel, Jacques M. T. de Bakker, Antonio Zaza (Herausgeber)

eBook Download: PDF

2007 | 2007
VIII, 182 Seiten
Springer Berlin (Verlag)
978-3-540-72110-9 (ISBN)

Infos

The development of a bio-engineered pacemaker is of substantial clinical and also scientific interest because it promises to overcome several limitations of electronic pacemakers. Moreover it may answer the longstanding question of whether the complex structure of the sinus node is indeed a prerequisite for reliable pacemaking, or simpler structures might work as well.

This book gives an overview of the current state-of-the-art of creating a bio-engineered pacemaker. It shows the approaches to develop of genetic and cell-based engineering methods suitable to implement them with safety and stability. It also illuminates the problems that need to be solved before bio-pacemaking can be considered for clinical use.

Inhalt

Contents 7
Biopacemaking: Clinically Attractive, Scientifically a Challenge 9
Embryological Development of Pacemaker Hierarchy and Membrane Currents Related to the Function of the Adult Sinus Node: Implications for Autonomic Modulation of Biopacemakers 14
Creation of a Biological Pacemaker by Gene- or Cell- Based Approaches 35
Creating a Cardiac Pacemaker by Gene Therapy 53
Biological Pacemakers Based on If 71
Gene Therapy to Create Biological Pacemakers 87
Inhibition of Cardiomyocyte Automaticity by Electrotonic Application of Inward Rectifier Current from Kir2.1 Expressing Cells 102
Propagation of Pacemaker Activity 113
Computer Modelling of the Sinoatrial Node 129
Application of Mesenchymal Stem Cell-Derived Cardiomyocytes as Bio- pacemakers: Current Status and Problems to Be Solved 157
Enrichment of Cardiac Pacemaker-Like Cells:Neure gulin-1 and Cyclic amp Increase If-Current Densityand Connexin 40 mRNA Levels in Fetal Cardiomyocytes 176
List of Contributors 186

Produkt-Details

• Erscheint lt. Verlag: 8.8.2007
• Reihe/Serie: Series in Biomedical Engineering
• Reihe/Serie: Series in Biomedical Engineering
• Zusatzinfo: VIII, 182 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Mathematik / Informatik ► Informatik
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik ► Elektrotechnik / Energietechnik
• Schlagworte: Cardiac Signals • Cells • Computer • Electrocardiogram • IFMBE
• ISBN-10: 3-540-72110-X / 354072110X
• ISBN-13: 978-3-540-72110-9 / 9783540721109