Molecular Analysis of B Lymphocyte Development and Activation (eBook)

Harinder Singh, Rudolf Grosschedl (Herausgeber)

eBook Download: PDF

2006 | 2005
XI, 260 Seiten
Springer Berlin (Verlag)
978-3-540-26363-0 (ISBN)

Infos

The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation.

Inhalt

Preface 5
Obituary 6
List of Contents 8
List of Contributors 9
Gene Regulatory Networks Orchestrating B Cell Fate Specification, Commitment, and Differentiation 10
1 Introduction 10
2 Specification and Commitment to the B Cell Fate 11
3 Regulation of Ig Gene Rearrangement and Pre-B Cell Differentiation 17
4 Conclusions and Perspectives 19
References 19
Helix-Loop-Helix Proteins in Lymphocyte Lineage Determination 23
1 Introduction 23
2 E2A Proteins 25
3 Class VI HLH Proteins: Hes-1/5 28
4 Id Proteins 28
5 Conclusions and Future Directions 29
References 32
Ikaros-Family Proteins: In Search of Molecular Functions During Lymphocyte Development 36
1 Introduction 37
2 Discovery 37
3 Structure and Family Members 38
4 Genetics 40
5 Localization to Centromeric Heterochromatin 42
6 Centromere Structure and Function 44
7 Centromere Role During Interphase 46
8 Potential Ikaros Functions at Pericentromeric Heterochromatin 47
9 Future Directions 49
References 50
Biochemistry of V(D)J Recombination 55
1 Introduction 56
2 DNA Transactions in V(D)J Recombination 59
3 Proteins That Mediate V(D)J Recombination 60
4 Recent Insights from In Vitro Cleavage Studies 68
5 Sequence-Specific Binding of the Recombination Signal by RAG1 and RAG2 73
6 Future Prospects 81
7 Epilogue 82
References 84
The pre-B cell Receptor in B Cell Development: Recent Advances, Persistent Questions and Conserved Mechanisms 92
1 Introduction 93
2 Commitment to the B Cell Lineage 94
3 The Development of Pre-B Cells 95
4 Initiating Signals Through the Pre-BCR 96
5 Different Signals for Different Functions 99
6 The Pre-TCR and Pre-BCR: Conservation of Signaling Properties and Functions? 101
7 Final Comments 102
References 103
Transcriptional Control of B Cell Activation 109
1 Introduction 110
2 Octamer-Binding Proteins and Cofactors 113
3 Rel-NF- kB Family Proteins 118
4 Pax-5/BSAP 123
5 Ets-1 Family Proteins 125
6 Ikaros Family Proteins 128
7 NF-AT Family Proteins 129
8 Other Transactivators Implicated in B Cell Activation 130
9 Concluding Remarks 134
References 136
Expression of MHC II Genes 151
1 Innate and Adaptive Immunity 152
2 Class II Transactivator 161
3 Conclusions and Future Directions 169
References 170
Class Switch Recombination: An Emerging Mechanism 175
1 Introduction 176
2 Overview of CSR 177
3 A Model for the Initiation and Resolution Steps in CSR 179
4 CSR and SHM Uncoupled 188
5 Genome Instability Syndromes and CSR 189
6 Targeting Mechanisms in CSR 191
7 Concluding Remarks 197
References 198
Blimp-1 Immunoglobulin Secretion and the Switch to Plasma Cells
1 Plasma Cell Biology 205
2 Transcriptional Regulation of Ig Secretion 208
3 Blimp-1-Regulated Maturation Program 212
4 Post-translational Regulation of Ig Secretion 220
5 Remarks and Future Directions 222
References 224
Wnt Signaling in Lymphopoiesis 228
1 Overview of the Different Wnt Signaling Pathways 229
2 The Canonical Wnt Signaling Pathway 230
3 Biochemical and Biological Properties of LEF/TCF Proteins 232
4 Activation of LEF1/TCF Function by b- Catenin and Other Cofactors 235
5 Transcriptional Repression and Inhibition of LEF1/TCF Function 237
6 Hematopoiesis 238
7 Role of the Wnt Pathway in Hematopoietic Stem Cells 240
8 Role of Wnt Signaling in Pro-B cell Proliferation and Survival 241
9 Role of Wnt Signaling in T Cell Development 243
10 Role of LEF/TCF in NK Cell Development 246
11 Concluding Remarks 247
References 247
Subject Index 256

Produkt-Details

• Erscheint lt. Verlag: 30.3.2006
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Zusatzinfo: XI, 260 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: B cell receptor • biochemistry • Cell • class switch recombination • Cytokine • cytokine receptors • DNA-binding proteins • Gene • genes • Immunoglobulin • Protein • proteins • transcriptional regulators
• ISBN-10: 3-540-26363-2 / 3540263632
• ISBN-13: 978-3-540-26363-0 / 9783540263630