Regulation of Sertoli Cell and Germ Cell Differentiation (eBook)

R. Brehm, Klaus Steger (Autoren)

eBook Download: PDF

2005 | 2005
X, 95 Seiten
Springer Berlin (Verlag)
978-3-540-29446-7 (ISBN)

Infos

Unwanted childlessness affects approximately one in six couples worldwide. - though the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization (WHO), in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. Based on these ?gures, the - cidence of male factor infertility in the general population is approximately 7%. The majority of these men, approximately 30%, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer, which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression, and tumour progression may be favoured by an aberrant Sertoli cell-germ cell communication.

Inhalt

Preface 5
Acknowledgements 7
List of Contents 8
1 Spermatogenesis 10
2 The Sertoli Cell 16
3 The Differentiation of Male Germ Cells 45
4 Idiopathic Male Infertility: Impaired Histone-to-Protamine Exchange? 54
5 Carcinoma In Situ of the Testis and Testicular Germ Cell Tumour: Impaired Intercellular Communication Due to Altered Sertoli Cell Differentiation? 58
References 80
Subject Index 103

Produkt-Details

• Erscheint lt. Verlag: 12.12.2005
• Reihe/Serie: Advances in Anatomy, Embryology and Cell Biology
• Reihe/Serie: Advances in Anatomy, Embryology and Cell Biology
• Zusatzinfo: X, 95 p. 26 illus., 3 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: germ cell tumor • haploid spermatids • Infertility • male infertility • Spermatogenesis • Spermatogonial Stem Cells • testicular disorders
• ISBN-10: 3-540-29446-5 / 3540294465
• ISBN-13: 978-3-540-29446-7 / 9783540294467