Insights into Receptor Function and New Drug Development Targets (eBook)

P. Michael Conn, Claude Kordon (Herausgeber)

eBook Download: PDF

2006 | 2006
XV, 202 Seiten
Springer Berlin (Verlag)
978-3-540-34447-6 (ISBN)

Infos

This book describes the current state of knowledge in receptor function in the development of new drugs. Science is on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The book reviews the availability of state-of-the-art tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.

Inhalt

Introduction 5
Table of Contents 7
List of Contributors 9
Molecular and functional diversity of the TRPC family of ion channels. TRPC channels and their role in ROCE/SOCE 16
Functional Rescue of Misfolded Receptor Mutants 38
Obesity-relatedmutations of leptin and melanocortin receptors 50
cAMP- and cGMP-dependent control of lipolysis and lipid mobilization in humans: putative targets for fat cell management 68
Central Neuropeptide Receptors Involved inWater Balance: Application to Apelin 94
Targeting regulators of G protein signaling (RGS proteins) to enhance agonist specificity 108
Dimeric GPCRs: what did we learn from the metabotropic glutamate receptors? 120
Guiding principles applied in the design of GPCR-selective hypothalamic hormone agonists and antagonists 132
Mutations in G proteins and G protein-coupled receptors in human endocrine diseases 154
Amolecular dissection of the glycoprotein hormone receptors 166
Receptor Tyrosine Kinases as Targets for Cancer Therapy Development 182
Targets for pituitary tumor therapy 194
The endogenous cannabinoid system in the control of food intake and energy balance 204
Subject Index 216

Produkt-Details

• Erscheint lt. Verlag: 28.9.2006
• Reihe/Serie: Research and Perspectives in Endocrine Interactions
• Reihe/Serie: Research and Perspectives in Endocrine Interactions
• Zusatzinfo: XV, 202 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Themenwelt: Medizin / Pharmazie ► Pharmazie
• Themenwelt: Medizin / Pharmazie ► Studium
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Cannabinoid • endogenous cannabinoid system • glycoprotein hormone receptors • G protein-coupled receptors • G Proteins • hormone receptors • ion channels • lipolysis • melanocortin receptors • metabotropic glutamate receptors • receptor tyrosine kinases • RGS proteins • TRPC channels
• ISBN-10: 3-540-34447-0 / 3540344470
• ISBN-13: 978-3-540-34447-6 / 9783540344476