Animal Models of T Cell-Mediated Skin Diseases (eBook)

T. Zollner, Harald Renz, Khusru Asadullah (Herausgeber)

eBook Download: PDF

2007 | 2005
XIII, 291 Seiten
Springer Berlin (Verlag)
978-3-540-26811-6 (ISBN)

Infos

Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The '50th International Workshop of the Ernst Schering Research Foundation' focussed on 'Animal Models of T Cell-Mediated Skin Diseases'. Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.

Inhalt

Preface 5
Contents 7
List of Editors and Contriiutors 9
1 Making Gene-Modified Mice 14
2 High-Throughput Gene Knockouts and Phenottping in Mice 40
3 Modelling Gene-Environment Interactions in Th1-and Th2-Dominated Diseases of Laboratory Animals 58
4 AnimalModels of Experimental Asthma 82
5 Models of Rheumatoid Arthritis 101
6 Animal Models of Inflammatort Bowel Diseases 130
7 Murine Models of Atopic Dermatitis 144
8 Epicutaneous Sensitiiation with Allergens as an Atopic Dermatitis Model 178
9 T-Cell Receptor Transgenic Models of Inflammatort Disorders: Relevance for Atopic Dermatitis? 186
10 What Must a Model Display for Proof as a Modelof Psoriasis? 203
11 From Classical Mouse Models of Psoriasis to a Spontaneous Xenograft Model Featuring Use of AGR Mice 212
12 The Psoriasis SCID Mouse Model: A Toolfor Drug Discovert? 222
13 Pro-and Anti-inflammatort Effects of IL-4: From Studies in Mice to Therapy of Autoimmune Diseases in Humans 244
14 What Must a Model Display for Proof as a Modelof Contact Dermatitis? 252
15 Acute and Chronic Models of Allergic Contact Dermatitis: Advantages and Limitations 263
16 Transgenic Mice Expressing IFN-y in the Epidermis Are a Model of Inflammatory Skin Disease and Ststemic Lupus Ertthematosus 284

Produkt-Details

• Erscheint lt. Verlag: 19.1.2007
• Reihe/Serie: Ernst Schering Foundation Symposium Proceedings
• Reihe/Serie: Ernst Schering Foundation Symposium Proceedings
• Zusatzinfo: XIII, 291 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
• Themenwelt: Medizin / Pharmazie ► Studium
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie ► Physikalische Chemie
• Themenwelt: Technik
• Schlagworte: Animal Models of Skin Diseases • Asthma • Atopic Dermatitits • contact dermatitis • Gene-modified mice • genes • Psoriasis
• ISBN-10: 3-540-26811-1 / 3540268111
• ISBN-13: 978-3-540-26811-6 / 9783540268116