Transposons and the Dynamic Genome (eBook)

Dirk-Henner Lankenau, Jean-Nicolas Volff (Herausgeber)

eBook Download: PDF

2009 | 2009
XV, 184 Seiten
Springer Berlin (Verlag)
978-3-642-02005-6 (ISBN)

Infos

This volume gives an overview on mobile DNA and how such contradiction to the obligatory stability of genomes can be understood. Obviously, an understanding can only be achieved by cutting deeply into the evolutionary history of life.

Inhalt

Preface 6
Contents 14
Theoretical Approaches to the Dynamics of Transposable Elements in Genomes, Populations, and Species 17
1 Introduction 17
2 Genome Colonization 18
3 TE – Genome Coevolution 25
4 Conclusion 29
References 30
Infra- and Transspecific Clues to Understanding the Dynamics of Transposable Elements 36
1 Introduction 36
2 Lessons from the Past 38
3 Towards an Understanding of TE Regulation. From Sequence to Epigenetics 42
4 Conclusion 50
References 52
Morphological Characters from the Genome: SINE Insertion Polymorphism and Phylogenies 59
1 On the Importance of Getting the Phylogeny Right 59
2 SINEs 61
3 SINE Insertion Polymorphisms as Characters for Phylogeny 62
4 Methods 73
5 Conclusion 79
References 80
Genome Defense Against Transposable Elements and the Origins of Regulatory RNA 90
1 The Ascent of Regulatory RNA 90
2 RNAi and Genome Defense 92
3 TEs and microRNAs 94
4 Repeat-Associated Sequences and piRNAs 96
5 Transcript Infection Model 101
References 103
When Drosophila Meets Retrovirology: The gypsy Case 108
1 Introduction 108
2 Historical Background 110
3 Finding the Road to the Germline 111
4 Origin of the gypsy Env 112
5 Structural Analysis of gypsy Env 115
6 Functional Analysis of gypsy Env 116
7 Role of gypsy Env 116
8 Conclusion 117
References 118
Transposon–Host Cell Interactions in the Regulation of Sleeping Beauty Transposition 121
1 Introduction 122
2 The Sleeping Beauty Transposable Element: Structure and Mechanism of Transposition 122
3 Regulation of Transposition 123
4 Concluding Remarks 136
References 136
Interactions of Transposons with the Cellular DNA RepairMachinery 145
1 Introduction 146
2 The Types of DNA Damage Produced by Transposons 146
3 Cellular Processes Potentially Involved in Signaling and Repairing Transposition Intermediates 147
4 The Main Classes of Transposons 152
5 Repetitive Elements and Genome Stability 173
6 Transposition and Cell Cycle 175
7 Concluding Remarks 177
References 178
Subject Index 189

Produkt-Details

• Erscheint lt. Verlag: 30.6.2009
• Reihe/Serie: Genome Dynamics and Stability
• Reihe/Serie: Genome Dynamics and Stability
• Zusatzinfo: XV, 184 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Activation • Chromosom • chromosome • DNA • Evolution • genes • Metabolism • recombination • Regulation • RNA
• ISBN-10: 3-642-02005-4 / 3642020054
• ISBN-13: 978-3-642-02005-6 / 9783642020056