Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy (eBook)

Carlos A. Zarate Jr., Husseini K. Manji (Herausgeber)

eBook Download: PDF

2009 | 2009
XII, 279 Seiten
Springer Basel (Verlag)
978-3-7643-8567-5 (ISBN)

Infos

Although our knowledge of mood disorders is expanding, comparatively little is known about bipolar depression in particular. This book offers the most up-to-date information about the diagnosis, treatment, and research surrounding bipolar depression.

Early chapters provide diagnostic information and review the course, outcome and genetics of this heritable condition. The book gives a thorough and unique overview of the neurobiology of the disorder, including neuroimaging work. Several chapters delineate the treatment of bipolar depression in special populations such as children and pregnant women. Furthermore, the particular issues of suicide, focusing on the need for assessment during both acute and maintenance treatment, are addressed. Finally, acute and long-term treatment strategies for bipolar depression are discussed, including both traditional and novel therapeutics, as well as non-pharmacological treatments.

This volume offers researchers and clinicians key insights into this devastating disorder.

Inhalt

Contents 6
List of contributors 8
Acknowledgements 10
Foreword 11
Section A: Bipolar depression: Clinical phenotype and course of illness 13
The history of bipolar disorders 14
The clinical diagnosis of bipolar depression 28
Course and outcome of bipolar disorder – focusing on depressive aspects 40
Suicide and bipolar disorder 58
Section B: Bipolar depression: Neurobiology 68
The genetic basis of bipolar disorder 69
Understanding the neurobiology of bipolar depression 87
Non-pharmacological treatments and chronobiological aspects of bipolar disorder: implications for novel therapeutics 105
Neuroimaging studies of bipolar depression: therapeutic implications 127
Section C: Acute and long-term treatment of bipolar disorder 155
Pharmacological treatment of acute bipolar depression 156
Pharmacological treatment of the maintenance phase of bipolar depression: focus on relapse prevention studies and the impact of design on generalizability 168
Non-pharmacological somatic treatments for bipolar depression 188
Potential novel treatments for bipolar depression 200
Section D: Treatment of bipolar disorder in special populations 219
Late-onset bipolar disorder 220
Treatment of childhood-onset bipolar disorder 247
Treatment of bipolar disorder during and after pregnancy 259
Conclusion 276
Index 280
The MDT-Series Milestones in Drug Therapy 285

Produkt-Details

• Erscheint lt. Verlag: 16.4.2009
• Reihe/Serie: Milestones in Drug Therapy
• Reihe/Serie: Milestones in Drug Therapy
• Zusatzinfo: XII, 279 p. 16 illus., 3 illus. in color.
• Verlagsort: Basel
• Sprache: englisch
• Themenwelt: Geisteswissenschaften
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
• Themenwelt: Medizin / Pharmazie ► Pharmazie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Assessment • Bipolar Depression • Bipolar Disorder • Depression • Diagnosis • Focusing • Genetics • Intervention • Mood Disorder • Neurobiology • neuroimaging • Neuroscience • pharmacotherapy • Psychopharmacology • Suicide • Women
• ISBN-10: 3-7643-8567-7 / 3764385677
• ISBN-13: 978-3-7643-8567-5 / 9783764385675