Synaptic Plasticity and the Mechanism of Alzheimer's Disease (eBook)

Dennis J. Selkoe, Antoine Triller (Herausgeber)

eBook Download: PDF

2008 | 2008
XII, 183 Seiten
Springer Berlin (Verlag)
978-3-540-76330-7 (ISBN)

Infos

A biochemical hypothesis - that Alzheimer's disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused on understanding how early assemblies of Ab may compromise some of these synapses.

Inhalt

Preface 5
Table of Contents 6
List of Contributors 8
Permanence of the Synapse andMolecular Instability 12
Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity 30
Imaging of Experience-Dependent Structural Plasticity in theMouse Neocortex in vivo 47
Synapse Loss, Synaptic Plasticity and the Postsynaptic Density 60
Impact of Beta Amyloid on Excitatory Synaptic Transmission and Plasticity 72
Quantitative Neuropathology in Alzheimer’sMouse Models 78
Multiple Levels of Synaptic Regulation by NMDA-type Glutamate Receptor in Normal and Disease States 83
Soluble Oligomers of the Amyloid ß-Protein: Impair Synaptic Plasticity and Behavior 96
Why Alzheimer’s is a Disease ofMemory: Synaptic Targeting by Pathogenic Aß Oligomers (ADDLs) 110
Synaptic Transmission Dynamically Modulates Interstitial Fluid Amyloid-ß Levels 140
Aß-Induced ToxicityMediated by Caspase Cleavage of the Amyloid Precursor Protein (APP) 151
Long-Term Potentiation and Aß: TargetingAß Species, CellularMechanisms and Putative Receptors 162
Genes, Synapses and Autism Spectrum Disorders 173
Subject Index 184

Produkt-Details

• Erscheint lt. Verlag: 8.1.2008
• Reihe/Serie: Research and Perspectives in Alzheimer's Disease
• Reihe/Serie: Research and Perspectives in Alzheimer's Disease
• Zusatzinfo: XII, 183 p. 34 illus., 26 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Medizin / Pharmazie ► Studium
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: ADDL • Alzheimer • Alzheimer's disease • Amyloid precursor protein • Attention Deficit Disorder (ADD) • Autism • Autism spectrum disorder • beta amyloid • brain • Cortex • glutamate receptor • Memory • mouse neocortex • Parkinson • postsynaptic density • receptor • receptor trafficking • synapse loss
• ISBN-10: 3-540-76330-9 / 3540763309
• ISBN-13: 978-3-540-76330-7 / 9783540763307