Structural and Functional Organization of the Synapse (eBook)

Michael D. Ehlers, Johannes W. Hell (Herausgeber)

eBook Download: PDF

2008 | 2008
XVIII, 801 Seiten
Springer US (Verlag)
978-0-387-77232-5 (ISBN)

Infos

This new Springer volume, which comes complete with a free DVD, is a comprehensive and detailed overview of the synapse with emphasis on the glutamatergic synapse. Most chapters relate the synapse's functional aspects to its molecular mechanisms. This approach shows which mechanisms are characterized on both the functional and structural level and can thus be considered firmly established. It's an important text for neuroscientists and disease-oriented clinicians in neurology.

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The synapse is a fascinating structure for many reasons. Biologically, it is an exquisitely organized subcellular compartment that has a remarkable capacity for fidelity and endurance. Computationally, synapses play a central role in signal transmission and processing that represent evolution's solution to learning and memory. Nervous systems, including our own brains, possess an extraordinary capacity for adaptation and memory because the synapse, not the neuron, constitutes the basic unit for information storage. Because the molecular complexities underlying signal processing and information storage must occur within the tiny space of the synapse, the precise molecular organization of proteins, lipids, and membranes at the synapse is paramount. Given the central role of the synapse in neuronal communication, it comes as no surprise that dysregulation of the synapse accounts for many, if not most, neurological and psychiatric disorders. Clinically, the synapse thus constitutes a prime target for treatments of these diseases. It is for these reasons that we have chosen to focus our work on deciphering the structural and functional organization of the synapse. We have assembled leaders in the field of synapse biology to describe and distill the wonders and mysteries of the synapse. This book provides a fundamental description of the synapse developed over many decades by numerous investigators, paired with recent insight into new aspects of synapse structure and function that is still in flux and at the cutting edge of research.

Inhalt

Diversity in Synapse Structure and Composition.- The Role of Glutamate Transporters in Synaptic Transmission.- Structure and Function of Vertebrate and Invertebrate Active Zones.- Neurotransmitter Release Machinery: Components of the Neuronal SNARE Complex and Their Function.- The Molecular Machinery for Synaptic Vesicle Endocytosis.- Initiation and Regulation of Synaptic Transmission by Presynaptic Calcium Channel Signaling Complexes.- Adhesion Molecules at the Synapse.- Dendritic Organelles for Postsynaptic Trafficking.- Structure and Mechanism of Action of AMPA and Kainate Receptors.- Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity.- Structure and Function of the NMDA Receptor.- Molecular Properties and Cell Biology of the NMDA Receptor.- Surface Trafficking of Membrane Proteins at Excitatory and Inhibitory Synapses.- Scaffold Proteins in the Postsynaptic Density.- Ca2+ Signaling in Dendritic Spines.- Postsynaptic Targeting of Protein Kinases and Phosphatases.- Long-Term Potentiation.- Homeostatic Synaptic Plasticity.- Ubiquitin and Protein Degradation in Synapse Function.- Signaling from Synapse to Nucleus.- Molecular Organization of the Postsynaptic Membrane at Inhibitory Synapses.- Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology.- Glia as Active Participants in the Development and Function of Synapses.- Plasticity of Dentate Granule Cell Mossy Fiber Synapses: A Putative Mechanism of Limbic Epileptogenesis.- Stroke – A Synaptic Perspective.- and Pathological Pain.

Produkt-Details

• Erscheint lt. Verlag: 25.6.2008
• Zusatzinfo: XVIII, 801 p. 91 illus., 72 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• Schlagworte: Alzheimer • biochemistry • Neurology • neurons • Physiology
• ISBN-10: 0-387-77232-4 / 0387772324
• ISBN-13: 978-0-387-77232-5 / 9780387772325